Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Poteser, M; Graziani, A; Eder, P; Yates, A; Mächler, H; Romanin, C; Groschner, K.
Identification of a rare subset of adipose tissue-resident progenitor cells, which express CD133 and TRPC3 as a VEGF-regulated Ca2+ entry channel.
FEBS Lett. 2008; 582(18):2696-2702
Doi: 10.1016/j.febslet.2008.06.049
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- Führende Autor*innen der Med Uni Graz
- Mächler Heinrich
- Poteser Michael
- Co-Autor*innen der Med Uni Graz
- Groschner Klaus
- Yates Ameli
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- Abstract:
- VEGF-induced Ca2+ signalling was investigated in CD133+/VEGFR-2+ progenitor cells isolated from human adipose stroma. Colonies derived from CD133+ immunoselected cells displayed inhomogenous Ca2+ signals, with variable magnitude of VEGF-induced Ca2+ entry, which positively correlated with expression of the Ca2+ channel protein TRPC3. High levels of VEGF-induced Ca2+ entry and TRPC3 expression were preferentially detected in rim areas of expanding colonies. Dominant negative suppression of TRPC3 inhibited VEGF-induced Ca2+ entry into CD133+ cells. Our results identify TRPC3 as a key Ca2+ entry channel in a subset of CD133+ stem cells. We suggest TRPC3 as an essential determinant of cell fate in CD133+ progenitor-derived colonies.
- Find related publications in this database (using NLM MeSH Indexing)
- Adipose Tissue - cytology Adipose Tissue - drug effects Adipose Tissue - metabolism
- Adult -
- Aged -
- Aged, 80 and over -
- Antigens, CD - biosynthesis
- Calcium Channels - biosynthesis Calcium Channels - genetics
- Cell Differentiation -
- Cell Line -
- Cells, Cultured -
- Female -
- Glycoproteins - biosynthesis
- Humans -
- Male -
- Middle Aged -
- Neovascularization, Physiologic -
- Peptides -
- Stem Cells - cytology Stem Cells - drug effects Stem Cells - metabolism
- TRPC Cation Channels - biosynthesis TRPC Cation Channels - genetics
- Vascular Endothelial Growth Factor A - metabolism Vascular Endothelial Growth Factor A - pharmacology
- Find related publications in this database (Keywords)
- CD133(+)
- TRPC3
- Ca2+ entry
- tissue-specific progenitor cells
- VEGF signalling
- adipose tissue