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SHR Neuro Cancer Cardio Lipid Metab Microb

Bieback, K; Schallmoser, K; Klutera, H; Strunk, D.
Clinical Protocols for the isolation and expansion of mesenchymal stromal cells
TRANSFUS MED HEMOTHER. 2008; 35(4): 286-294. Doi: 10.1159/000141567 [OPEN ACCESS]
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Co-authors Med Uni Graz: Schallmoser Katharina; Strunk Dirk
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Abstract:: Multipotent mesenchymal stromal cells (MSCs) are currently exploited in numerous clinical trials to investigate their potential in immune regulation, hematopoiesis, and tissue regeneration. The low frequency of MSCs necessitates cell expansion to achieve transplantable numbers. The challenge is to assure safe and high-quality cell production. GMP(Good Manufacturing Practice)-graded cell processing such as cell preparation, culture, and manipulation is mandatory for the progress of such advanced cell therapy. This review summarizes protocols to isolate MSCs from bone marrow and adipose tissue and to expand MSCs for clinical use focussing on culture media composition as well as culture devices and assays to ensure and control quality of the final product.
Find related publications in this database (Keywords): mesenchymal stromal cells, multipotent; clinical-scale expansion; Good Manufacturing Practice (GMP)