Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Holzer-Petsche, U; Petritsch, W; Hinterleitner, T; Eherer, A; Sperk, G; Krejs, GJ.
Effect of neuropeptide Y on jejunal water and ion transport in humans.
Gastroenterology. 1991; 101(2):325-330
Doi: 10.1016/0016-5085(91)90007-8
Web of Science
PubMed
FullText
FullText_MUG
Google Scholar
- Führende Autor*innen der Med Uni Graz
- Holzer Ulrike
- Co-Autor*innen der Med Uni Graz
- Eherer Andreas
- Hinterleitner Thomas
- Krejs Günter Josef
- Petritsch Wolfgang
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- Neuropeptide Y is a neurotransmitter in enteric and postganglionic sympathetic neurons. In animal models of intestinal water and ion transport, neuropeptide Y decreases stimulated secretion but has no consistent effect on basal transport. In the present study, the effect of neuropeptide Y on jejunal water and electrolyte transport in healthy volunteers was investigated under basal conditions and during intestinal secretion induced by intraluminal administration of prostaglandin E2. The triple-lumen tube technique was used for perfusion of the small intestine with a plasmalike electrolyte solution containing polyethylene glycol as a nonabsorbable volume marker. After an initial control period (saline IV) neuropeptide Y was administered IV at a dose of 400 pmol.kg-1.h-1. Neuropeptide Y significantly increased net absorption of water, sodium, potassium, and chloride under basal conditions. The peptide significantly reduced the secretion of these electrolytes induced by an intraluminal prostaglandin E2 concentration of 5 mumol/L and reduced net water secretion by 36%. The results of the current study suggest that neuropeptide Y can change intestinal water and ion transport from secretion toward absorption.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Bicarbonates - metabolism
- Chlorides - metabolism
- Dinoprostone - pharmacology
- Female -
- Humans -
- Intestinal Absorption - drug effects
- Jejunum - drug effects Jejunum - secretion
- Male -
- Neuropeptide Y - blood Neuropeptide Y - pharmacology
- Potassium - metabolism
- Sodium - metabolism
- Water - metabolism
- Water-Electrolyte Balance - drug effects