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SHR Neuro Cancer Cardio Lipid Metab Microb

Hogan, Q; Lirk, P; Poroli, M; Rigaud, M; Fuchs, A; Fillip, P; Ljubkovic, M; Gemes, G; Sapunar, D.
Restoration of calcium influx corrects membrane hyperexcitability in injured rat dorsal root ganglion neurons.
Anesth Analg. 2008; 107(3):1045-1051 Doi: 10.1213/ane.0b013e31817bd1f0 [OPEN ACCESS]
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Co-authors Med Uni Graz: Fuchs Andreas; Gemes Geza; Rigaud Marcel
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Abstract:: BACKGROUND: We have previously shown that a decrease of inward Ca(2+) flux (I(Ca)) across the sensory neuron plasmalemma, such as happens after axotomy, increases neuronal excitability. From this, we predicted that increasing I(Ca) in injured neurons should correct their hyperexcitability. METHODS: The influence of increased or decreased I(Ca) upon membrane biophysical variables and excitability was determined during recording from A-type neurons in nondissociated dorsal root ganglia after spinal nerve ligation using an intracellular recording technique. RESULTS: When the bath Ca(2+) level was increased to promote I(Ca), the after-hyperpolarization was decreased and repetitive firing was suppressed, which also followed amplification of Ca(2+)-activated K(+) current with selective agents NS1619 and NS309. A decreased external bath Ca(2+) concentration had the opposite effects, similar to previous observations in uninjured neurons. CONCLUSIONS: These findings indicate that at least a part of the hyperexcitability of somatic sensory neurons after axotomy is attributable to diminished inward Ca(2+) flux, and that measures to restore I(Ca) may potentially be therapeutic for painful peripheral neuropathy.
Find related publications in this database (using NLM MeSH Indexing): Animals -; Behavior, Animal -; Benzimidazoles - pharmacology; Calcium - chemistry; Ganglia, Spinal - embryology; Indoles - pharmacology; Male -; Models, Biological -; Neurons - metabolism; Neurons, Afferent - metabolism; Oximes - pharmacology; Potassium - chemistry; Rats -; Rats, Sprague-Dawley -; Spinal Nerves - pathology