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Hansen, MB; Thørboll, JE; Beubler, E; Skadhauge, E.
Effect of indomethacin, renzapride, methysergide, ketanserin, granisetron and citalopram on serotonin-induced fluid accumulation in pig jejunum.
Physiol Res. 1994; 43(2):83-93 [OPEN ACCESS]
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Co-authors Med Uni Graz: Beubler Eckhard
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Abstract:: The purpose of this study was to elucidate the intestinal serotonin (5-HT) receptor subtypes involved in fluid transport in the pig jejunum in vivo. The fluid accumulating effect of intraluminally administered 5-HT, renzapride, methysergide, ketanserin, granisetron, citalopram and intravenous indomethacin, was tested in tied-off loops in vivo. 5-HT caused a dose-dependent fluid accumulation, which was reduced by indomethacin by about 30%. Renzapride, methysergide, ketanserin, granisetron and citalopram all caused fluid accumulation. Taking into account these fluid accumulating effects, renzapride, methysergide, ketanserin and granisetron reduced the fluid accumulating effect of 5-HT, giving a maximal reduction of 70, 46, 76, and 80%, respectively. These data suggest the existence of intestinal 5-HT receptor subtypes involved in fluid transport in the pig jejunum. The antagonistic effects of indomethacin, ketanserin and granisetron, suggest the involvement of prostaglandins, as well as the 5-HT2 and the 5-HT3 receptor subtypes in the fluid accumulating response of 5-HT.
Find related publications in this database (using NLM MeSH Indexing): Animals -; Benzamides - pharmacology; Bicyclo Compounds - pharmacology; Bicyclo Compounds, Heterocyclic - pharmacology; Citalopram - pharmacology; Dose-Response Relationship, Drug - pharmacology; Granisetron - pharmacology; Indomethacin - pharmacology; Intestinal Absorption - drug effects; Jejunum - drug effects; Ketanserin - pharmacology; Methysergide - pharmacology; Receptors, Serotonin - drug effects; Serotonin - metabolism; Serotonin Antagonists - pharmacology; Swine - pharmacology