Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Hansen, MB; Thørboll, JE; Beubler, E; Skadhauge, E.
Effect of indomethacin, renzapride, methysergide, ketanserin, granisetron and citalopram on serotonin-induced fluid accumulation in pig jejunum.
Physiol Res. 1994; 43(2):83-93
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- Beubler Eckhard
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- Abstract:
- The purpose of this study was to elucidate the intestinal serotonin (5-HT) receptor subtypes involved in fluid transport in the pig jejunum in vivo. The fluid accumulating effect of intraluminally administered 5-HT, renzapride, methysergide, ketanserin, granisetron, citalopram and intravenous indomethacin, was tested in tied-off loops in vivo. 5-HT caused a dose-dependent fluid accumulation, which was reduced by indomethacin by about 30%. Renzapride, methysergide, ketanserin, granisetron and citalopram all caused fluid accumulation. Taking into account these fluid accumulating effects, renzapride, methysergide, ketanserin and granisetron reduced the fluid accumulating effect of 5-HT, giving a maximal reduction of 70, 46, 76, and 80%, respectively. These data suggest the existence of intestinal 5-HT receptor subtypes involved in fluid transport in the pig jejunum. The antagonistic effects of indomethacin, ketanserin and granisetron, suggest the involvement of prostaglandins, as well as the 5-HT2 and the 5-HT3 receptor subtypes in the fluid accumulating response of 5-HT.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Benzamides - pharmacology
- Bicyclo Compounds - pharmacology
- Bicyclo Compounds, Heterocyclic - pharmacology
- Citalopram - pharmacology
- Dose-Response Relationship, Drug - pharmacology
- Granisetron - pharmacology
- Indomethacin - pharmacology
- Intestinal Absorption - drug effects
- Jejunum - drug effects
- Ketanserin - pharmacology
- Methysergide - pharmacology
- Receptors, Serotonin - drug effects
- Serotonin - metabolism
- Serotonin Antagonists - pharmacology
- Swine - pharmacology