Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Stranzl, H; Zurl, B.
Postoperative irradiation of left-sided breast cancer patients and cardiac toxicity. Does deep inspiration breath-hold (DIBH) technique protect the heart?
Strahlenther Onkol. 2008; 184(7):354-358
Doi: 10.1007/s00066-008-1852-0
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Stranzl-Lawatsch Heidi
- Co-Autor*innen der Med Uni Graz
- Zurl Brigitte
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- Abstract:
- Purpose: To evaluate the impact of deep inspiration breath-hotd (DIBH) technique during postoperative Left-sided tangential breast irradiation on minimizing irradiated heart amount compared to normal breathing. Patients and Methods: In 22 patients with Left-sided breast cancer, postoperative CT scanning was performed in different respiratory phases using the Varian Real-time Position Management System (TM) for monitoring of respiratory chest wall motion. Each patient underwent two CT scans: during normal breathing and DIBH. For each scan, an optimized plan was designed with tangential photon fields encompassing the clinical target volume after breast-conserving surgery or modified radical mastectomy. The resulting dose-volume histograms were compared between both breathing techniques for irradiated volume and dose to the heart. Results: The mean patient age was 51 years (range: 34-77 years). The DIBH-gated technique was well accepted by all patients. The significant reduction in dose to the irradiated heart volume for the DIBH technique compared to the normal breathing was 56% (mean heart dose: 2.3 Gy vs. 1.3 Gy; p = 0.01). Conclusion: This study demonstrates that irradiated cardiac volumes can significantly be reduced in Left-sided breast cancer patients using DIBH technique for postoperative tangential radiotherapy. Moreover, the technique is safe and feasible in daily routine.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Antineoplastic Combined Chemotherapy Protocols - therapeutic use
- Breast Neoplasms - drug therapy Breast Neoplasms - radiography Breast Neoplasms - radiotherapy Breast Neoplasms - surgery
- Chemotherapy, Adjuvant -
- Female -
- Heart - radiation effects
- Humans -
- Image Processing, Computer-Assisted -
- Imaging, Three-Dimensional -
- Inhalation -
- Mastectomy, Modified Radical -
- Mastectomy, Segmental -
- Middle Aged -
- Radiation Injuries - prevention & control
- Radiotherapy -
- Radiotherapy Dosage -
- Radiotherapy Planning, Computer-Assisted -
- Radiotherapy, Adjuvant -
- Tomography, X-Ray Computed -
- Find related publications in this database (Keywords)
- left-sided breast carcinoma
- deep inspiration breath-hold technique
- cardiac toxicity
- postoperative radiotherapy