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SHR Neuro Cancer Cardio Lipid Metab Microb

Goswami, N; Grasser, E; Roessler, A; Schneditz, D; Hinghofer-Szalkay, H.
The cardiovascular response to lower body negative pressure in humans depends on seal location.
Physiol Res. 2009; 58(3): 311-318. Doi: 10.33549/physiolres.931431 [OPEN ACCESS]
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Leading authors Med Uni Graz: Goswami Nandu
Co-authors Med Uni Graz: Hinghofer-Szalkay Helmut; Rössler Andreas; Schneditz Daniel
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Abstract:: We tested whether seal location at iliac crest (IC) or upper abdomen (UA), before and during lower body negative pressure (LBNP), would affect thoracic electrical impedance, hepatic blood flow, and central cardiovascular responses to LBNP. After 30 min of supine rest, LBNP at -40 mm Hg was applied for 15 min, either at IC or UA, in 14 healthy males. Plasma density and indocyanine green concentrations assessed plasma volume changes and hepatic perfusion. With both sealing types, LBNP-induced effects remained unchanged for mean arterial pressure (-3.0+/-1.1 mm Hg), cardiac output (-1.0 l min(-1)), and plasma volume (-11 %). Heart rate was greater during UA (80.6+/-3.3 bpm) than IC (76.0+/-2.5 bpm) (p<0.01) and thoracic impedance increased more using UA (3.2+/-0.2 Omega) than IC (1.8+/-0.2 Omega) (p<0.0001). Furthermore, during supine rest, UA was accompanied by lower thoracic impedance (26.9+/-1.1 vs 29.0+/-0.8 Omega, p<0.001) and hepatic perfusion (1.6 vs 1.8 l.min(-1), p<0.05) compared to IC. The data suggest that the reduction in central blood volume in response to LBNP depends on location of the applied seal. The sealing in itself altered blood volume distribution and hepatic perfusion in supine resting humans. Finally, application of LBNP with the seal at the upper abdomen induced a markedly larger reduction in central blood volume and greater increases in heart rate than when the seal was located at the iliac crest.
Find related publications in this database (using NLM MeSH Indexing): Adult -; Blood Pressure -; Cardiac Output -; Cardiovascular Physiological Processes -; Electric Impedance -; Fluid Shifts -; Heart Rate -; Humans -; Liver Circulation -; Lower Body Negative Pressure - methods; Male -; Plasma Volume -; Supine Position -; Young Adult -
Find related publications in this database (Keywords): Abdominal compression; Central blood volume; Orthostasis; Splanchnic blood flow; Thoracic electrical impedance