Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Pilz, S; Dobnig, H; Fischer, JE; Wellnitz, B; Seelhorst, U; Boehm, BO; März, W.
Low vitamin d levels predict stroke in patients referred to coronary angiography.
Stroke. 2008; 39(9): 2611-2613.
Doi: 10.1161/STROKEAHA.107.513655
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- Führende Autor*innen der Med Uni Graz
- März Winfried
- Pilz Stefan
- Co-Autor*innen der Med Uni Graz
- Dobnig Harald
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- Abstract:
- BACKGROUND AND PURPOSE: Vitamin D deficiency is common among the elderly and may contribute to cerebrovascular diseases. We aimed to elucidate whether low vitamin D levels are predictive for fatal stroke. METHODS: The LUdwigshafen RIsk and Cardiovascular Health (LURIC) study includes 3316 patients who were referred to coronary angiography at baseline between 1997 and 2000. 25-Hydroxyvitamin D [25(OH)D] and 1,25-dihydroxyvitamin D [1,25(OH)2D] were measured in 3299 and 3315 study participants, respectively. To account for the seasonal variation of vitamin D metabolites, we calculated z values for the 25(OH)D and 1,25(OH)2D concentrations within each month of blood draw. RESULTS: During a median follow-up time of 7.75 years, 769 patients died, including 42 fatal (ischemic and hemorrhagic) strokes. When compared with survivors in binary logistic-regression analyses, the odds ratios (with 95% CIs) for fatal stroke were 0.58 (0.43 to 0.78; P<0.001) per z value of 25(OH)D and 0.62 (0.47 to 0.81; P<0.001) per z value of 1,25(OH)2D. After adjustment for several possible confounders, these odds ratios remained significant for 25(OH)D at 0.67 (0.46 to 0.97; P=0.032) and for 1,25(OH)2D at 0.72 (0.52 to 0.99; P=0.047). Z values of 25(OH)D and 1,25(OH)2D were also reduced in the 274 patients who had a history of previous cerebrovascular disease events at baseline. CONCLUSIONS: Low levels of 25(OH)D and 1,25(OH)2D are independently predictive for fatal strokes, suggesting that vitamin D supplementation is a promising approach in the prevention of strokes.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Cerebral Arteries - metabolism
- Cohort Studies -
- Comorbidity -
- Coronary Angiography -
- Coronary Artery Disease - blood
- Dietary Supplements - standards
- Female -
- Humans -
- Incidence -
- Male -
- Middle Aged -
- Mortality -
- Multivariate Analysis -
- Prospective Studies -
- Regression Analysis -
- Stroke - blood
- Vitamin D - blood
- Vitamin D Deficiency - blood
- Find related publications in this database (Keywords)
- stroke
- vitamins
- epidemiology