Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Pieske, B; Wachter, R.
Impact of diabetes and hypertension on the heart.
Curr Opin Cardiol. 2008; 23(4):340-349
Doi: 10.1097/HCO.0b013e3283031ab3
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Pieske Burkert Mathias
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- Abstract:
- Purpose of review Hypertension and diabetes both contribute to cardiovascular disease. The purpose of this review is to summarize novel epidemiological and clinical insights into the risk continuum of blood pressure and abnormalities in glucose metabolism for cardiovascular adverse remodelling, summarize the current mechanistic knowledge on hypertensive heart disease and diabetic cardiomyopathy, outline the effects of hypertension and diabetes on diastolic dysfunction and heart failure with normal ejection fraction, and discuss novel therapeutic aspects in these disease entities. Recent findings The prevalence of diabetes mellitus and hypertension increases in western populations and largely contributes to adverse cardiovascular remodelling and the growing number of patients with heart failure. Recently, diastolic heart failure (i.e., heart failure with normal ejection fraction) has been recognized as a major adverse manifestation of hypertension and diabetes, but convincing therapeutic strategies other than strict risk factor control are still lacking. However, due to clearer definitions and novel noninvasive diagnostic techniques for heart failure with normal ejection fraction, future studies may better define new specific therapeutic approaches. Summary New insights into the epidemiology and pathophysiology of diabetes-associated and hypertension-associated cardiac alterations may open the field for novel preventive therapeutic strategies tailored to reduce the risk of heart failure in this large population at risk.
- Find related publications in this database (using NLM MeSH Indexing)
- Blood Pressure - physiology
- Diabetes Complications - physiopathology
- Heart - physiopathology
- Heart Failure, Diastolic - etiology Heart Failure, Diastolic - physiopathology Heart Failure, Diastolic - therapy
- Humans -
- Hypertension - complications Hypertension - physiopathology Hypertension - therapy
- Risk Factors -
- Find related publications in this database (Keywords)
- diabetes
- diabetic cardiomyopathy
- diastolic heart failure
- hypertension
- hypertensive heart disease