Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Konstantinjuk, P; Schrenk, P; Reitsamer, R; Koeberle-Wuehrer, R; Tausch, C; Roka, S; Riedle, O; Poestiberger, S; Hecke, D; Janauer, M; Haid, A.
A nonrandomized follow-up comparison between standard axillary node dissection and sentinel node biopsy in breast cancer.
BREAST. 2007; 16(5): 520-526.
Doi: 10.1016/j.breast.2007.04.001
Web of Science
PubMed
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FullText_MUG
- Leading authors Med Uni Graz
- Konstantiniuk Peter
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- Abstract:
- Introduction: In many countries sentinel node biopsy (SNB) has become the standard of care in breast cancer based on a large number of observational studies but without results from prospective randomized trials. The goat of our study was to evaluate the oncological safety of the SNB in breast cancer in a multicenter, norrandomized setting with comparable groups. Patients and methods: Between 1996/05 and 2004/11, 2942 patients from 14 departments in Austria with unicentric, unilateral, invasive disease without neoadjuvant therapy were collected in a database. The recommendations of the Austrian Sentinel Node Study Group were to complete a training period (phase 1) with 50 cases of SNB followed by axillary lymph node dissection (ALND) to prove a detection rate of >= 90% and a fatse-negative rate of <= 5%. In the executing period (phase 11), SNB was followed by ALND only if the sentinel node (SN) contained metastases. We compared the results on disease-free survival, local recurrence rates, distant recurrence rates and overall survival of both groups. Cases from phases I and II generated groups 1 (n = 671) and 2 (n = 2271 cases), respectively. Results: Overall mean follow-up time: 34.41 months [GRAPHICS] Conclusion: SNB followed by ALND only in cases with metastases in the SN is a safe procedure and at least equal to ALND in all cases. (c) 2007 Elsevier Ltd. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Austria -
- Axilla - pathology
- Breast Neoplasms - mortality
- Disease-Free Survival - mortality
- Female - mortality
- Humans - mortality
- Lymph Node Excision - mortality
- Lymph Nodes - pathology
- Lymphatic Metastasis - pathology
- Middle Aged - pathology
- Neoplasm Recurrence, Local - mortality
- Neoplasm Staging - mortality
- Predictive Value of Tests - mortality
- Sensitivity and Specificity - mortality
- Sentinel Lymph Node Biopsy - mortality
- Survival Analysis - mortality
- Find related publications in this database (Keywords)
- breast cancer
- sentinel node biopsy
- follow-up
- recurrences
- disease-free survival
- overall survival