Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Schintler, MV; Prandl, EC.
Vacuum-assisted closure - what is evidence based?
EUR SURG. 2008; 40(1): 11-18.
Doi: 10.1007/s10353-008-0381-5
Web of Science
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- Führende Autor*innen der Med Uni Graz
- Schintler Michael
- Co-Autor*innen der Med Uni Graz
- Prandl-Mira Eva-Christina
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- Abstract:
- Background: VAC - vacuum-assisted closure, synonymous with TNP ( topical negative pressure) or VT ( Vacuum therapy) is a mode of therapy used to encourage wound healing. It is used both as primary treatment of chronic and complex wounds and as an adjunct for temporary closure and wound bed preparation preceding surgical procedures such as skin grafts and flap surgery. The device has come into wide and successful use although the physiological basis of its effect is not yet understood and few evidence-based data are available. Methods: A meta-analysis was made of peer-reviewed publications (PubMed-Medline) chosen on the basis of inclusion of the terms, randomised clinical trials, vacuum-assisted closure, and topical negative pressure. Results: Scientific data were evaluated from experimental animal studies, randomised clinical trials, observations of clinical applications and case reports on all known effects of VAC therapy. Systematic analysis of the data shows efficacy concerning induction of wound-healing mechanisms, especially in the early stage. Increased perfusion can be considered proven. Data analysis shows positive efficacy for the treatment of infection. Conclusions: Although this therapy appears effective, its superiority to conventional techniques has not been demonstrated. Because its mechanisms of action remain unclear, and as there is a gap between evidence-based data and the excellent clinical results, further prospective randomised blinded studies are needed. Even so, we conclude that VT ( vacuum therapy), used when indicated especially by experienced surgeons, is an excellent tool to support wound healing.
- Find related publications in this database (Keywords)
- vacuum-assisted closure
- conventional wound treatment
- randomised clinical trials
- evidence-based medicine