Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
ARCHELOS, JJ; MAURER, M; JUNG, S; TOYKA, KV; HARTUNG, HP.
Suppression of experimental allergic neuritis by an antibody to the intracellular adhesion molecule ICAM-1.
Brain. 1993; 116 ( Pt 5)(11):1043-1058
Doi: 10.1093/brain/116.5.1043
Web of Science
PubMed
FullText
FullText_MUG
Google Scholar
- Führende Autor*innen der Med Uni Graz
- Archelos-Garcia Juan-Jose
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- Experimental allergic (autoimmune) neuritis (EAN) was induced in Lewis rats either by inoculation with bovine spinal root myelin or injection of neuritogenic P2-specific T cells. Injection of a purified monoclonal antibody (1A-29) to the intercellular adhesion molecule-1 (ICAM-1) prevented or transiently suppressed myelin-induced EAN depending on the timing of antibody application. Administration of 1A-29 suppressed moderate adoptive transfer EAN (AT-EAN) but not severe AT-EAN. In contrast, treatment with phosphate buffered saline or an unrelated IgG1 had no effect on the course of the disease. Histological sections of the peripheral nervous system (PNS) showed a marked reduction of inflammatory infiltrates and perivascular demyelination in rats injected with 1A-29. The effect of 1A-29 on the concanavalin A (Con A)- and P2-dependent proliferation of neuritogenic P2-specific T cells was studied in vitro. Our data suggest that antibodies to ICAM-1 act on the induction and effector phase of the immune response by inhibiting both early interactions between immunocompetent cells after exposure to foreign antigen and transendothelial migration of primed T cells into the peripheral nerve. Treatment with antibodies to leucocyte adhesion molecules could be a useful therapeutic approach to autoimmune disease of the PNS.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Antibodies, Monoclonal - immunology
- Cell Adhesion Molecules - immunology
- Cell Division - drug effects
- Concanavalin A - pharmacology
- Female - pharmacology
- Immunoglobulin G - therapeutic use
- Immunotherapy, Adoptive - therapeutic use
- Intercellular Adhesion Molecule-1 - therapeutic use
- Myelin Basic Proteins - therapeutic use
- Myelin P2 Protein - therapeutic use
- Neuritis, Autoimmune, Experimental - immunology
- Peripheral Nerves - pathology
- Rats - pathology
- Rats, Inbred Lew - pathology
- T-Lymphocytes - cytology