Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
HARTUNG, HP; MICHELS, M; REINERS, K; SEELDRAYERS, P; ARCHELOS, JJ; TOYKA, KV.
Soluble ICAM-1 serum levels in multiple sclerosis and viral encephalitis.
Neurology. 1993; 43(11):2331-2335
Doi: 10.1212/WNL.43.11.2331
Web of Science
PubMed
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FullText_MUG
- Co-Autor*innen der Med Uni Graz
- Archelos-Garcia Juan-Jose
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- Abstract:
- Intercellular adhesion molecule ICAM-1 has a crucial role in the induction of an immune response and is instrumental in migration of T cells into inflamed tissue. We studied soluble ICAM-1 concentrations in patients with multiple sclerosis (MS), viral encephalitis, and other immunologic diseases, and compared results with those in other noninflammatory, nondemyelinating neurologic disorders as well as in healthy controls. MS patients with clinically active disease or enhancing lesions on MRI had elevated serum levels of soluble ICAM-1. Concentrations of soluble ICAM-1 were also increased in some patients with viral encephalitis. These findings raise the possibility that circulating ICAM-1 serves as a marker of acute inflammatory events in the brain and add to evidence implicating this adhesion molecule in the pathogenesis of MS.
- Find related publications in this database (using NLM MeSH Indexing)
- Cell Adhesion Molecules - blood
- Encephalitis - immunology
- Enzyme-Linked Immunosorbent Assay - immunology
- Female - immunology
- Herpesviridae Infections - immunology
- Humans - immunology
- Intercellular Adhesion Molecule-1 - immunology
- Male - immunology
- Multiple Sclerosis - immunology