Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
ZIELASEK, J; ARCHELOS, JJ; TOYKA, KV; HARTUNG, HP.
Expression of intercellular adhesion molecule-1 on rat microglial cells.
Neurosci Lett. 1993; 153(2):136-139
Doi: 10.1016/0304-3940(93)90306-6
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- Co-Autor*innen der Med Uni Graz
- Archelos-Garcia Juan-Jose
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- Abstract:
- Microglial cells isolated from newborn rat brain displayed a baseline immunoreactivity for intercellular adhesion molecule-1 (ICAM-1) after 10-20 days in culture. ICAM-1 immunoreactivity was enhanced in a time-dependent fashion by exposing the microglial cells to recombinant rat gamma-interferon (gamma-IFN; 100 U/ml) or tumor necrosis factor-alpha (TNF-alpha; 1000 U/ml). We conclude that rat brain macrophages/microglial cells can be induced by gamma-IFN and TNF-alpha to express ICAM-1. This may be relevant in the interaction of microglial cells with other brain cells during inflammation of the central nervous system.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Animals, Newborn -
- Cell Adhesion Molecules - biosynthesis
- Cells, Cultured - biosynthesis
- Flow Cytometry - biosynthesis
- Fluorescence - biosynthesis
- Immunohistochemistry - biosynthesis
- Intercellular Adhesion Molecule-1 - biosynthesis
- Interferon Type II - pharmacology
- Neuroglia - metabolism
- Rats - metabolism
- Rats, Inbred Lew - metabolism
- Tumor Necrosis Factor-alpha - pharmacology
- Find related publications in this database (Keywords)
- MICROGLIAL CELL
- LEUKOCYTE ADHESION MOLECULE
- GAMMA-INTERFERON
- TUMOR NECROSIS FACTOR-ALPHA
- MULTIPLE SCLEROSIS
- INFLAMMATION