Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
STOLL, G; JANDER, S; JUNG, S; ARCHELOS, J; TAMATANI, T; MIYASAKA, M; TOYKA, KV; HARTUNG, HP.
Macrophages and endothelial cells express intercellular adhesion molecule-1 in immune-mediated demyelination but not in Wallerian degeneration of the rat peripheral nervous system.
Lab Invest. 1993; 68(6):637-644
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- Co-Autor*innen der Med Uni Graz
- Archelos-Garcia Juan-Jose
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- Abstract:
- BACKGROUND: Intercellular adhesion molecule-1 (ICAM-1) plays an important role in immune responses, especially in T cell/endothelial cell and T cell/macrophage interactions. This study reports the cellular localization of ICAM-1 during immune-mediated demyelination of the peripheral nervous system induced by adoptive transfer of P2 specific T cells. EXPERIMENTAL DESIGN: Cryosections 1 micron thick of ventral roots of rats with experimental autoimmune neuritis were labeled with a monoclonal antibody against rat ICAM-1. RESULTS: Numerous ICAM-1 positive cells were present before and shortly after the onset of clinical disease from days 4 to 6 after cell transfer. By day 8, their number had greatly decreased. ICAM-1 positive infiltrating cells could be identified as ED1 positive macrophages. Moreover, endothelial cells expressed ICAM-1. Schwann cells and T cells were ICAM-1 negative. While at early stages of experimental autoimmune neuritis, ICAM-1 and Ia colocalized on macrophages but not endothelial cells, Ia persisted for a longer period in nerve roots than ICAM-1. After nerve transection, macrophages entering the distal stump and endothelial cells did not express ICAM-1. CONCLUSIONS: The presence of ICAM-1 immunoreactivity in peripheral nerve indicates an underlying immune-mediated process. Among other cytokines interferon-gamma, which is transiently expressed in nerves during immune-mediated demyelination but not after nerve transection, could be one mediator that induces ICAM-1 in immune-mediated demyelination of the peripheral nervous system.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Cell Adhesion Molecules - analysis
- Demyelinating Diseases - immunology
- Disease Models, Animal - immunology
- Endothelium - immunology
- Female - immunology
- Intercellular Adhesion Molecule-1 - immunology
- Macrophages - immunology
- Peripheral Nervous System Diseases - immunology
- Rats - immunology
- Rats, Inbred Lew - immunology
- T-Lymphocytes - immunology
- Wallerian Degeneration - immunology
- Find related publications in this database (Keywords)
- EXPERIMENTAL ALLERGIC NEURITIS
- T-CELLS
- AXOTOMY
- INTERFERON-GAMMA