Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Nauman, A; Porta, S; Bardowska, U; Fiedorowicz, K; Sadjak, A; Korsatko, W; Nauman, J.
The effect of adrenaline pretreatment on the in vitro generation of 3,5,3'-triiodothyronine and 3,3',5'-triiodothyronine (reverse T3) in rat liver preparation.
HORMONE METAB RES. 1984; 16(9): 471-474.
Doi: 10.1055/s-2007-1014822
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- Co-Autor*innen der Med Uni Graz
- Porta Sepp
- Sadjak Anton
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- Abstract:
- The effects of adrenaline (A) on liver T3 and rT3 neogenesis from T4 were studied in Wistar rats. The animals were implanted subcutaneously either with A or placebo (P) especially coated tablets which linearly released the hormone. The serum A values 6 hrs after implantation of 7.5, 15.0 and 45.0 mg tablets were 6.5 +/- 1.31, 6.8 +/- 1.8 and 16.4 +/- 1.9 ng/ml, respectively vs 4.4 +/- 2.5 ng/ml seen in P pretreated group. The output rates of A were 0.11 (7.5 mg), 0.18 (15 mg) and 0.52 microgram/ml (45 mg). The pretreatment with A led to hyperglycemia and the "low T3 syndrome". Neogenesis of T3 from T4 in medium containing liver microsomes of P pretreated rats was 5.49 +/- 0.25 pmol of T3/mg protein/min and decreased in A pretreated rats to 3.82 +/- 0.17, 3.12 +/- 0.27 and 3.06 +/- 0.11 pmol of T3/mg of protein/min. Neogenesis of rT3 from T4 in microsomes from P group was 1.52 +/- 0.09 pmol rT3/mg protein/min and increased after A to 2.71 +/- 0.11, 2.60 +/- 0.21 and 2.21 +/- 0.34 pmol of rT3/mg protein/min thus showing no dose dependency. Enrichment of microsomes medium with cytosol either from P or A pretreated rats had no effect on T3 generation thus excluding effect of A on cytosolic cofactor. Although cytosol further increased rT3 neogenesis this was seen regardless of whether cytosol was obtained from A or P implanted rats. It is concluded that A decreases the activity of T4-5'-deiodinase in liver, and possibly increases the activity of T4-5-deiodinase.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Coenzymes - metabolism
- Cytosol - enzymology
- Epinephrine - pharmacology
- In Vitro - pharmacology
- Iodide Peroxidase - metabolism
- Liver - enzymology
- Male - enzymology
- Microsomes, Liver - enzymology
- Rats - enzymology
- Rats, Inbred Strains - enzymology
- Research Support, Non-U.S. Gov't - enzymology
- Thyroxine - metabolism
- Triiodothyronine - biosynthesis
- Triiodothyronine, Reverse - biosynthesis