Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Dornbusch, HJ; Sovinz, P; Lackner, H; Schwinger, W; Benesch, M; Strenger, V; Urban, C.
Effective management of pulmonary aspergillosis invading the thoracic spine in a child with high risk ALL requiring allogeneic bone marrow transplantation.
Med Mycol. 2008; 46(5):487-490
Doi: 10.1080/13693780801930746
(- Case Report)
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- Führende Autor*innen der Med Uni Graz
- Dornbusch Hans Jürgen
- Co-Autor*innen der Med Uni Graz
- Benesch Martin
- Lackner Herwig
- Ritter-Sovinz Petra
- Schwinger Wolfgang
- Strenger Volker
- Urban Ernst-Christian
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- Abstract:
- Due to unacceptably high mortality, invasive fungal infections (IFI) have long been considered a contraindication against allogeneic stem cell transplantation. Despite severe immunosuppression an 11-year-old girl requiring allogeneic bone marrow transplant (BMT) for relapsed acute lymphoblastic leukemia was cured of a concurrent invasive pulmonary aspergillosis. Treatment comprised combinations of liposomal amphotericin B, caspofungin and voriconazole with donor granulocyte transfusions. This therapeutic regimen, including the choice of reduced intensity conditioning (RIC), allowed the patient to receive an allogeneic BMT. In hematological remission the child later developed fatal chronic graft-versus-host disease. Combined antifungal treatment and granulocyte support allow for effective management of IFI even in allogeneic stem cell transplant recipients. However, short-term benefits of RIC may be outweighed by late complications.
- Find related publications in this database (using NLM MeSH Indexing)
- Adoptive Transfer -
- Amphotericin B - therapeutic use
- Antifungal Agents - therapeutic use
- Aspergillosis, Allergic Bronchopulmonary - therapy
- Bone Marrow Transplantation -
- Child -
- Echinocandins - therapeutic use
- Female -
- Graft vs Host Disease -
- Granulocytes - immunology
- Humans -
- Precursor Cell Lymphoblastic Leukemia-Lymphoma - complications
- Pyrimidines - therapeutic use
- Radiography, Thoracic -
- Spine - microbiology Spine - pathology
- Triazoles - therapeutic use
- Find related publications in this database (Keywords)
- aspergillosis
- non-myeloablative allogeneic BMT
- granulocyte transfusions
- combination antifungal treatment