Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Sommer, C; Lackner, H; Benesch, M; Sovinz, P; Schwinger, W; Moser, A; Bergloeff, J; Gruber, A; Urban, C.
Neuroophthalmological side effects following intrathecal administration of liposomal cytarabine for central nervous system prophylaxis in three adolescents with acute myeloid leukaemia.
Ann Hematol. 2008; 87(11): 887-890.
Doi: 10.1007/s00277-008-0521-9
(- Case Report)
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- Führende Autor*innen der Med Uni Graz
- Sommer Constanze
- Co-Autor*innen der Med Uni Graz
- Benesch Martin
- Bergloeff Jutta
- Gruber Anna
- Lackner Herwig
- Ritter-Sovinz Petra
- Schwinger Wolfgang
- Urban Ernst-Christian
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- Abstract:
- Three adolescents with central nervous system (CNS) negative acute myeloid leukaemia (AML) refused cranial irradiation for CNS prophylaxis. Instead, these patients received four doses of 50 mg of intrathecal (IT) liposomal cytarabine on day 1, 15, 43 and 71 of maintenance therapy. Corticosteroids were given to prevent chemical arachnoiditis. All patients developed bilateral papilloedema after the third or fourth dose of liposomal cytarabine, local side effects were observed in two patients. Under prolonged dexamethasone therapy, side effects resolved completely. As reversible neuroophthalmological side effects caused by intrathecal liposomal cytarabine can also be observed under low-dose maintenance therapy in patients with CNS negative AML, it should be used with caution in children and adolescents.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adrenal Cortex Hormones - therapeutic use
- Antimetabolites, Antineoplastic - administration and dosage Antimetabolites, Antineoplastic - adverse effects
- Cytarabine - administration and dosage Cytarabine - adverse effects
- Dexamethasone - therapeutic use
- Female -
- Humans -
- Injections, Spinal - adverse effects
- Leukemia, Myeloid, Acute - drug therapy
- Liposomes -
- Male -
- Papilledema - chemically induced Papilledema - drug therapy
- Remission Induction -
- Find related publications in this database (Keywords)
- acute myeloid leukaemia
- intrathecal chemotherapy
- liposomal cytarabine
- neuroophthalmological side effects