Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Gamillscheg, A; Holzer, P; Donnerer, J; Lembeck, F.
Effect of neonatal treatment with capsaicin on carrageenan-induced paw oedema in the rat.
Naunyn Schmiedebergs Arch Pharmacol. 1984; 326(4):340-342
Doi: 10.1007/BF00501439
Web of Science
PubMed
FullText
FullText_MUG
Google Scholar
- Führende Autor*innen der Med Uni Graz
- Gamillscheg Andreas
- Co-Autor*innen der Med Uni Graz
- Donnerer Josef
- Holzer Peter
- Lembeck Fred
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- The time course of the paw oedema induced by the subplantar injection of carrageenan was studied in rats treated neonatally with capsaicin and in their vehicle-treated controls. In the capsaicin-treated rats, which show a permanent deficit of unmyelinated primary sensory neurones, carrageenan produced an oedema which was larger and lasted longer than in the vehicle-treated rats. Pretreatment with the histamine liberator compound 48/80 reduced the carrageenan-induced paw oedema only in the capsaicin-treated rats whereas pretreatment with indomethacin reduced it in both groups of rats. The increased and prolonged inflammatory response to carrageenan in capsaicin-treated rats may be explained by an enhanced release of histamine from mast cells and may also reflect a 'trophic disorder of the denervated skin'.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Animals, Newborn -
- Capsaicin - pharmacology
- Carrageenan - pharmacology
- Edema - chemically induced
- Histamine Release - drug effects
- Indomethacin - pharmacology
- Male - pharmacology
- Rats - pharmacology
- Rats, Inbred Strains - pharmacology
- Time Factors - pharmacology
- p-Methoxy-N-methylphenethylamine - pharmacology