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SHR Neuro Cancer Cardio Lipid Metab Microb
Enzinger, C; Thimary, F; Kapeller, P; Ropele, S; Schmidt, R; Ebner, F; Fazekas, F.
Transient global amnesia: diffusion-weighted imaging lesions and cerebrovascular disease.
Stroke. 2008; 39(8): 2219-2225.
Doi: 10.1161/STROKEAHA.107.508655
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- Leading authors Med Uni Graz
- Enzinger Christian
- Co-authors Med Uni Graz
- Ebner Franz
- Fazekas Franz
- Kapeller Peter
- Ropele Stefan
- Schmidt Reinhold
- Thimary Felix
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- Abstract:
- BACKGROUND AND PURPOSE: A hypoxic-ischemic origin of transient global amnesia (TGA) has been suggested on the basis of the observation of infarctlike diffusion-weighted imaging (DWI) abnormalities in some affected individuals. We tested this hypothesis by comparing vascular risk factors, magnetic resonance imaging (MRI) markers of cerebral small-vessel disease, and other evidence of a cerebrovascular disorder between TGA patients with (DWI+) and without (DWI-) DWI lesions and normal community-based controls. METHODS: We retrospectively identified 86 patients hospitalized for TGA (mean+/-SD age, 65.9+/-10.9 years; 62% female). Brain MRI at 1.5 T was assessed for DWI lesions exhibiting restricted diffusion (ie, DWI+), white-matter hyperintensities, lacunes, and chronic infarcts (median time lag to clinical onset, 66.6+/-54.6 hours). Vascular risk factors and findings from duplex sonography, ECG, and echocardiography were recorded. A 1:2 age- and sex-matched sample of 172 elderly subjects (mean+/-SD age, 65.6+/-9.3 years; 62% female) free of neuropsychiatric disease served for comparison. RESULTS: DWI lesions were observed in 10 patients with TGA (11.5%; mean+/-SD age, 68.3+/-5.4 years; 8 women). They were all small and located in the mesiotemporal region (9 left hemisphere, 5 right hemisphere). The vascular risk profile of TGA patients and concomitant changes on brain MRI were comparable with those of healthy controls and did not show significant differences between DWI+ and DWI- subjects. A comprehensive diagnostic workup also provided no evidence for a higher rate of cerebrovascular disorder-related abnormalities in either the total group of TGA patients or TGA DWI+ patients. CONCLUSIONS: These findings do not support a cerebrovascular etiology of TGA, even in those individuals showing acute DWI lesions. Other pathophysiologic mechanisms need to be explored.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Amnesia, Transient Global - epidemiology
- Brain Infarction - epidemiology
- Brain Ischemia - epidemiology
- Cerebrovascular Circulation -
- Diffusion Magnetic Resonance Imaging -
- Female -
- Humans -
- Male -
- Microcirculation -
- Middle Aged -
- Retrospective Studies -
- Risk Factors -
- Ultrasonography, Doppler, Duplex -
- Find related publications in this database (Keywords)
- transient global amnesia
- amnestic syndrome
- magnetic resonance imaging
- diffusion-weighted imaging
- risk factors