Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Moinfar, F.
Is 'basal-like' carcinoma of the breast a distinct clinicopathological entity? A critical review with cautionary notes.
Pathobiology. 2008; 75(2):119-131
Doi: 10.1159/000123850
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- Leading authors Med Uni Graz
- Moinfar Farid
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- Abstract:
- This review deals with studies that have used cDNA microarrays and immunohistochemistry to identify a subtype of breast carcinoma known as basal-like carcinoma. The key breast carcinoma studies are critically discussed to highlight methodological problems in cohort selection, definitions, interpretation of results and statistical analysis. The review concludes that basal-like carcinomas do not reflect a single, biologically uniform group of breast cancers, but show significant variations in their phenotypes, grades, immunoprofiles and clinical behavior, just as a wide range of subtypes and behaviors is observed among epithelial/luminal-derived breast carcinomas. Well-designed studies with comparison of low-grade nonbasal versus low-grade basal and high-grade nonbasal versus high-grade basal carcinomas are necessary before one can be convinced that this subtype represents a distinct clinicopathological entity.
- Find related publications in this database (using NLM MeSH Indexing)
- Breast Neoplasms - diagnosis
- Carcinoma, Basal Cell - diagnosis
- DNA, Neoplasm - genetics
- Female -
- Gene Expression Regulation, Neoplastic -
- Humans -
- Oligonucleotide Array Sequence Analysis -
- Phenotype -
- Find related publications in this database (Keywords)
- breast carcinoma
- basal-like carcinoma
- microarrays
- molecular classification of tumors
- immunohistochemistry