Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Nöthig-Laslo, V; Jürgens, G; Holasek, A.
Comparative study of Ca2+ binding to lipoprotein(a) and low density lipoprotein by spin labeling.
Chem Phys Lipids. 1984; 35(2):143-150
Doi: 10.1016/0009-3084(84)90020-3
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- Jürgens Günther
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- Abstract:
- The effect of Ca2+ binding on the dynamic properties of various spin labeled fatty acids in lipoprotein(a) (Lp(a)) was studied in comparison with low density lipoprotein (LDL) isolated from human plasma. In contrast to LDL, binding of Ca2+ to Lp(a) induced broadening of the lines in the ESR spectra of the spin labeled stearic acids. In 1.6 M NaBr solutions the thermotropic change in the surface structure was observed in both lipoproteins at similar temperatures. Ten millimolar concentration of Ca2+ shifted the temperature of the thermotropic change in the surface structure of Lp(a) to considerably higher values. We conclude that Ca2+ binding to Lp(a) induces changes in the lipid structure of the particle surface.
- Find related publications in this database (using NLM MeSH Indexing)
- Calcium - metabolism
- Cyclic N-Oxides - metabolism
- Electron Spin Resonance Spectroscopy - metabolism
- Humans - metabolism
- Lipoprotein(a) - metabolism
- Lipoproteins - metabolism
- Lipoproteins, LDL - metabolism
- Spin Labels - metabolism