Medizinische Universität Graz - Research portal
Selected Publication:
Höfler, H; Denk, H.
Immunocytochemical demonstration of cytokeratin in gastrointestinal carcinoids and their probable precursor cells.
Virchows Arch A Pathol Anat Histopathol. 1984; 403(3):235-240
Doi: 10.1007/BF00694899
Web of Science
PubMed
FullText
FullText_MUG
Google Scholar
- Co-authors Med Uni Graz
- Denk Helmut
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- Occurrence and distribution of cytokeratin, neuron specific enolase (NSE) and actin were studied by the immunoperoxidase-antiperoxidase (PAP)-technique using specific antibodies in formalin-fixed, paraffin-embedded material from 6 cases of neurogenic appendicopathy with numerous endocrine cells in the mucosal stroma (SEC), 5 cases of microcarcinoidosis of the stomach, 12 gastrointestinal carcinoids and 4 bronchial carcinoids. Cytokeratin was detectable in all tumor cells. In addition, the epithelial endocrine cells (EEC) and the SEC of intestinal origin were cytokeratin positive. EEC, SEC and cells of microcarcinoids and carcinoids showed a positive immunoreactivity with antibodies to NSE, whereas actin antibodies did not reveal significant staining of these cells. These results strongly suggest that carcinoids of the gastrointestinal tract originate from SEC that have migrated downwards into the stroma from the epithelial layer (" Endophytie " according to Feyrter ).
- Find related publications in this database (using NLM MeSH Indexing)
- Carcinoid Tumor - analysis
- Gastrointestinal Neoplasms - analysis
- Histocytochemistry - analysis
- Humans - analysis
- Immunoenzyme Techniques - analysis
- Keratins - analysis