Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
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SHR Neuro Krebs Kardio Lipid Stoffw Microb
von Lewinski, D; Zhu, D; Khafaga, M; Kockskamper, J; Maier, LS; Hasenfuss, G; Pieske, B.
Frequency-dependence of the slow force response.
Front Biosci. 2008; 13(4): 7202-7209.
Doi: 10.2741/3222
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- Führende Autor*innen der Med Uni Graz
- Pieske Burkert Mathias
- von Lewinski Dirk
- Co-Autor*innen der Med Uni Graz
- Khafaga Mounir
- Kockskämper Jens
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- Abstract:
- Stretch induces biphasic inotropic effects in mammalian myocardium. A delayed component (slow force response, SFR) has been demonstrated in various species, however, experimental conditions varied and the underlying mechanisms are controversial. The physiological relevance of the SFR is poorly understood. Experiments were performed in ventricular muscle strips from failing human hearts and non-failing rabbit hearts. Upon stretch, twitch force was assessed at basal conditions (1 Hz, 37 degrees C) and after changing stimulation frequency with and without blockade of the Na+/H+-exchanger-1 (NHE1) or reverse-mode Na+/Ca2+-exchange (NCX). Action potential duration (APD) was assessed using floating electrodes. Low stimulation rates (0.2 Hz) potentiated and higher stimulation rates (2 and 3 Hz) reduced the SFR. The extent of SFR inhibition by NHE1 or NCX inhibition was not affected by stimulation rate. APD decreased at 0.2 Hz but was not altered at higher stimulation rates. The data demonstrate frequency-dependence of the SFR with greater positive inotropic effects at lower stimulation rates. Subcellular mechanisms underlying the SFR are not fundamentally affected by stimulation rate. The SFR may have more pronounced physiological effects at lower heart rates.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Diastole -
- Heart - physiology Heart - physiopathology
- Heart Failure - metabolism Heart Failure - physiopathology
- Heart Ventricles - physiopathology
- Humans -
- Kinetics -
- Mammals -
- Muscle, Smooth, Vascular - physiopathology
- Myocardium - metabolism
- Papillary Muscles - physiopathology
- Rabbits -
- Find related publications in this database (Keywords)
- Stretch
- Human Myocardium
- Contractile Function