Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Donnerer, J; Barthó, L; Holzer, P; Lembeck, F.
Intestinal peristalsis associated with release of immunoreactive substance P.
Neuroscience. 1984; 11(4):913-918
Doi: 10.1016/0306-4522(84)90202-1
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- Führende Autor*innen der Med Uni Graz
- Donnerer Josef
- Co-Autor*innen der Med Uni Graz
- Holzer Peter
- Lembeck Fred
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- Abstract:
- The release of immunoreactive substance P into the vascular bed of the isolated small intestine of the guinea-pig was investigated. Raising the intraluminal pressure to 5 mbar for 5 min initiated peristalsis and stimulated the release of substance P. The substance P releasing effect of pressure stimulation was reduced by 46% when hexamethonium (240 microM) was added to the perfusion solution. The ganglion stimulant drug dimethylphenylpiperazinium (32 microM) also stimulated the release of substance P; its effect was completely prevented by hexamethonium (240 microM). Intraarterial infusion of capsaicin (22 microM), a neurotoxin known to act on sensory substance P-containing neurones, stimulated the release of substance P and caused intestinal contractions. The motor effect of capsaicin in the gut can thus be explained by release of substance P from sensory nerve endings in the gut. Systemic pretreatment of the guinea-pigs with capsaicin abolished the release of substance P due to capsaicin, whereas that evoked by elevated intraluminal pressure or dimethylphenylpiperazinium was not reduced. This means that substance P released in the course of peristalsis or by dimethylphenylpiperazinium originates from neurones intrinsic to the intestine. These findings indicate that intestinal peristalsis is associated with the release of substance P from enteric neurones. Substance P is likely to be a neurotransmitter involved in the coordination of the peristaltic reflex.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Capsaicin - pharmacology
- Dimethylphenylpiperazinium Iodide - pharmacology
- Female -
- Gastrointestinal Motility -
- Guinea Pigs -
- Intestines - blood supply
- Male -
- Neurotransmitter Agents - physiology
- Potassium - pharmacology
- Reflex - physiology
- Substance P - blood
- Synaptic Transmission -