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Sicuteri, F; Geppetti, P; Marabini, S; Lembeck, F.
Pain relief by somatostatin in attacks of cluster headache.
PAIN. 1984; 18(4): 359-365. Doi: 10.1016/0304-3959(84)90048-4
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Co-authors Med Uni Graz: Lembeck Fred
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Abstract:: The pain relieving effect of somatostatin treatment during 72 attacks of cluster headache in 8 male patients was compared to treatment with ergotamine or placebo in a double-blind study. Infusion of somatostatin (25 micrograms/min for 20 min i.v.) reduced the maximal pain intensity and the duration of pain significantly compared to placebo treatment, and to a degree comparable to ergotamine tartrate treatment (250 micrograms i.m.). The results obtained provide new information concerning the possible mechanism of cluster headache attacks and suggest a new therapeutic approach.
Find related publications in this database (using NLM MeSH Indexing): Adult -; Cluster Headache - drug therapy; Double-Blind Method - drug therapy; Ergotamine - drug therapy; Ergotamines - therapeutic use; Humans - therapeutic use; Infusions, Parenteral - therapeutic use; Male - therapeutic use; Middle Aged - therapeutic use; Somatostatin - therapeutic use; Vascular Headaches - drug therapy