Medizinische Universität Graz - Research portal
Selected Publication:
Haas, A; Trummer, G; Eckhardt, M; Schmut, O; Uyguner, I; Pfeiffer, KP.
Effect of calcium dobesilate on progression of diabetic retinopathy
Klin Monatsbl Augenheilkd. 1995; 207(1):17-21
Doi: 10.1055/s-2008-1035343
Web of Science
PubMed
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FullText_MUG
- Leading authors Med Uni Graz
- Haas Anton
- Co-authors Med Uni Graz
- Schmut Otto
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- Abstract:
- BACKGROUND: The increase of platelet aggregation, plasma and whole blood viscosity and the decrease of red cell deformability in patients with diabetes mellitus may be causative in the development of retinopathy. A therapy influencing these factors maybe prevents retinopathy or slows progression. MATERIAL AND METHODS: In a clinical and prospective study over 2 years 74 patients aged 20 to 69 years with a mild background retinopathy were randomly assigned to take oral 3 x 500 mg calcium dobesilate (Doxium) or no therapy. Both groups did neither differ in demographic nor in laboratory data. In fluorescein angiography following characteristics of retinopathy were graded: microaneurysms, size and outline of foveal avascular zone, capillary loss and severity of dye leakage. Additionally in 15 patients contrast sensitivity, visual fields and oscillatory potentials were investigated. RESULTS: The results of the fluorescein angiographical characteristics revealed no statistically significant difference between both groups. In the oscillatory potentials a significant shortening of latency could be found in both groups, but there was no difference between the groups. CONCLUSION: A 2-years application of calcium dobesilate has no statistically significant influence on the progression of diabetic retinopathy.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Blood Viscosity - drug effects
- Calcium Dobesilate - administration and dosage
- Contrast Sensitivity - drug effects
- Diabetic Retinopathy - blood
- Erythrocyte Deformability - drug effects
- Female - drug effects
- Fluorescein Angiography - drug effects
- Follow-Up Studies - drug effects
- Humans - drug effects
- Male - drug effects
- Middle Aged - drug effects
- Platelet Aggregation - drug effects
- Platelet Aggregation Inhibitors - administration and dosage
- Prospective Studies - administration and dosage
- Visual Fields - drug effects
- Find related publications in this database (Keywords)
- Calcium Dobesilate
- Diabetic Retinopathy
- Fluorescein Angiography
- Oscillatory Potentials