Medizinische Universität Graz - Research portal
Selected Publication:
Bauer, M; Horn, LC; Kowalzik, J; Mair, W; Czerwenka, K.
C-erbB-2 amplification and expression in gestational trophoblastic disease correlates with DNA content and karyotype.
Gen Diagn Pathol. 1997; 143(2-3):185-190
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- Holzapfel-Bauer Margit
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- Abstract:
- The subject of this retrospective study was to evaluate the potential benefit of the c-erbB-2 oncogene amplification and expression in 27 complete hydatidiform moles as well as in 9 cases of persistent gestational trophoblastic disease defined by elevated serum beta-human choriongonadotropin. The persistent cases were histopathologically classified as 5 complete hydatidiform moles, 3 invasive moles and 1 choriocarcinoma. In addition, we determined the DNA content and the karyotype of the sex chromosomes. The data were correlated with the histopathologic characteristics of gestational trophoblastic diseases. Cases with c-erbB-2 amplification and expression in combination with DNA hyperploidy showed higher proliferation and a more aggressive behavior (2 complete hydatidiform moles with lung and liver metastases, 2 invasive moles and 1 choriocarcinoma). XY karyotype was evident in the choriocarcinoma and in two complete hydatidiform moles with advanced stage and DNA hyperploidy.
- Find related publications in this database (using NLM MeSH Indexing)
- DNA - analysis
- Female - analysis
- Gene Expression - analysis
- Genes, erbB-2 - genetics
- Humans - genetics
- Hydatidiform Mole - genetics
- Image Processing, Computer-Assisted - genetics
- Immunohistochemistry - genetics
- In Situ Hybridization, Fluorescence - genetics
- Karyotyping - genetics
- Ploidies - genetics
- Pregnancy - genetics
- Receptor, erbB-2 - metabolism
- Retrospective Studies - metabolism
- Trophoblastic Neoplasms - genetics
- Uterine Neoplasms - genetics
- X Chromosome - genetics
- Y Chromosome - genetics