Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Gruber-Olipitz, M; Strobel, T; Chen, WQ; Grotzer, MA; Quehenberger, F; Slavc, I; Lubec, G.
Synthesis, chaperoning, and metabolism of proteins are regulated by NT-3/TrkC signaling in the medulloblastoma cell line DAOY.
J PROTEOME RES. 2008; 7(5): 1932-1944.
Doi: 10.1021/pr700724a
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- Co-authors Med Uni Graz
- Quehenberger Franz
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- Abstract:
- The human medulloblastoma cell line DAOY was transfected with Tropomyosin receptor kinase (TrkC), a marker for good prognostic outcome. Following TrkC-activation by its ligand neurotrophin-3, protein extracts from DAOY cells were run on 2DE with subsequent MALDI-TOF-TOF analysis and quantification in order to detect downstream effectors. Protein levels of translational, splicing, processing, chaperone, protein handling, and metabolism machineries were shown to depend on neurotrophin-3-induced TrkC activation probably representing pharmacological targets.
- Find related publications in this database (using NLM MeSH Indexing)
- Amino Acid Sequence -
- Animals -
- Cell Line, Tumor -
- Child -
- Enzyme Activation -
- Humans -
- Medulloblastoma - chemistry
- Molecular Sequence Data -
- Neoplasm Proteins - chemistry
- Neurotrophin 3 - metabolism
- Prognosis -
- Receptor, trkC - metabolism
- Signal Transduction - physiology
- Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization -
- Tumor Markers, Biological - metabolism
- Find related publications in this database (Keywords)
- TrkC
- neurotrophin-3
- medulloblastoma
- 2D gel electrophoresis
- MALDI-TOF-TOF
- protein machinery