Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Lenart, J; Komanska, I; Jasinska, R; Pikula, S.
The induction of cytochrome P450 isoform, CYP4A1, by clofibrate coincides with activation of ethanolamine-specific phospholipid base exchange reaction in rat liver microsomes.
Acta Biochim Pol. 1998; 45(1): 119-126.
Doi: 10.18388/abp.1998_4294
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- Führende Autor*innen der Med Uni Graz
- Lenart Jacek
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- Abstract:
- Administration of a hypolipidaemic drug, clofibrate, to rats resulted, 24 h after a single intraperitoneal injection (250 mg/kg body weight), in pronounced enhancement of the rate of phosphatidylethanolamine (PE) synthesis via the PE-specific base exchange (PEBE) reaction in liver microsomes. This was accompanied by 3.4-fold activation of microsomal omega-hydroxylation of lauric acid by cytochrome P450 4A1 isoform (CYP4A1) and an increase in the protein content of this isoform in endoplasmic reticulum (ER) membranes. Since PE represents a class of phospholipids (PL) prerequisite for proper functioning of CYP4A1, and the PEBE reaction is an inducible pathway of PL synthesis in hepatocytes under metabolic stress, one may speculate that this reaction is switched on when extensive remodelling of PL molecular species or/and massive synthesis of lipid bilayer components for membrane assembly is required.
- Find related publications in this database (using NLM MeSH Indexing)
- Alkane 1-Monooxygenase -
- Animals -
- Antilipemic Agents - pharmacology
- Clofibrate - pharmacology
- Cytochrome P-450 Enzyme System - biosynthesis
- Enzyme Induction - biosynthesis
- Male - biosynthesis
- Microsomes, Liver - drug effects
- Mixed Function Oxygenases - biosynthesis
- Phosphatidylethanolamines - biosynthesis
- Rats - biosynthesis
- Rats, Wistar - biosynthesis
- Find related publications in this database (Keywords)
- phospholipid synthesis
- base exchange reaction
- cytochrome P450 4A1
- clofibrate
- peroxisome proliferators