Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
TROP, M; ANDERSON, TD; SCHIFFRIN, EJ; CARTER, EA.
Effect of chronic interleukin-2 treatment on RES phagocytic activity in the rat.
BURNS. 1992; 18(5): 387-389.
Doi: 10.1016/0305-4179(92)90037-U
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- Abstract:
- The effect of chronic interleukin-2 (IL-2) injection upon reticuloendothelial system (RES) function in the rat has been determined. Seven-day treatments with two doses of human recombinant IL-2 resulted in a dramatic reduction in the phagocytic uptake of the liver and spleen, while increasing the weight of both organs. There were dramatic histological changes in the intestine, liver and spleen as well. These results suggest that the chronic use of IL-2 can result in hepatic dysfunction, which is associated with altered RES phagocytic function.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Interleukin-2 - pharmacology
- Intestines - drug effects
- Liver - drug effects Liver - physiopathology
- Mononuclear Phagocyte System - drug effects Mononuclear Phagocyte System - physiology
- Organ Size - drug effects
- Phagocytosis - drug effects
- Rats -
- Spleen - drug effects Spleen - physiopathology