Medizinische Universität Graz - Research portal
Selected Publication:
Skofitsch, G; Saria, A; Lembeck, F.
Phenyldiguanide and capsaicin stimulate functionally different populations of afferent C-fibers.
NEUROSCI LETT. 1983; 42(1): 89-94.
Doi: 10.1016/0304-3940(83)90427-5
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- Co-authors Med Uni Graz
- Lembeck Fred
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- Abstract:
- Effects of phenyldiguanide (PDG) and capsaicin (CAP) were compared. (1) The reflex fall in blood pressure following PDG i.v. was only partially but that following CAP i.v. completely inhibited in capsaicin-desensitized rats. (2) Bilateral vagotomy in rats abolished cardiovascular reflexes by PDG i.v., but not those by CAP i.v. (3) Instillation of PDG into the rat trachea did not cause neurogenic plasma extravasation whereas CAP does. (4) Bronchial tone of guinea-pigs remained unchanged after PDG i.v. whereas it was increased by CAP i.v. It is concluded that PDG activates vagal afferent fibers which are distinct from the substance P-containing afferent fibers stimulated by CAP.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
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- Biguanides - pharmacology
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- Capillary Permeability - drug effects
- Capsaicin - pharmacology
- Hypotension - chemically induced
- Male - chemically induced
- Nerve Fibers - drug effects
- Rats - drug effects
- Rats, Inbred Strains - drug effects
- Reflex - drug effects
- Vagus Nerve - drug effects