Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Amann, R; Schuligoi, R; Lanz, I; Peskar, BA.
Effect of a 5-lipoxygenase inhibitor on nerve growth factor-induced thermal hyperalgesia in the rat.
Eur J Pharmacol. 1996; 306(1-3):89-91
Doi: 10.1016%2F0014-2999%2896%2900255-5
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- Führende Autor*innen der Med Uni Graz
- Amann Rainer
- Co-Autor*innen der Med Uni Graz
- Peskar Bernhard
- Schuligoi Rufina
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- Abstract:
- Intraplantar injection of mouse beta (2.5S) nerve growth factor (NGF) caused thermal hyperalgesia and stimulated release of immunoreactive leukotriene B4 from the rat paw skin. Both effects of NGF were prevented by the 5-lipoxygenase inhibitor, (R)-2-[4-quinolin-2-yl-methoxy)phenyl]-2-cyclopentyl acetic acid (BAY X1005). BAY X1005 did not affect bradykinin-induced thermal hyperalgesia. These results suggest the participation of 5-lipoxygenase products of arachidonate in NGF-induced local thermal hyperalgesia.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Heat -
- Hyperalgesia - chemically induced
- Leukotriene B4 - agonists
- Lipoxygenase Inhibitors - pharmacology
- Male - pharmacology
- Nerve Growth Factors - antagonists and inhibitors
- Pain Threshold - drug effects
- Quinolines - pharmacology
- Rats - pharmacology
- Rats, Sprague-Dawley - pharmacology
- Find related publications in this database (Keywords)
- Leukotriene
- NGF (Nerve Growth Factor)
- Thermal Hyperalgesia