Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Petru, E; Haas, J; Schaider, H; Sevin, BU.
Do cell cycle changes of human ovarian carcinoma cells after exposure to cytostatic drugs in vitro correlate with cytotoxicity?
GYNAKOL GEBURTSHILFL RUNDSCH. 1995; 35 Suppl 1: 15-18.
Doi: 10.1159/000272557
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Petru Edgar
- Co-Autor*innen der Med Uni Graz
- Haas Josef
- Schaider Helmut
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- Abstract:
- OBJECTIVES: Is there a correlation between cell cycle perturbations and cytotoxicity in ovarian cancer cells exposed to cytotoxic drugs in vitro? METHODS: We tested the association between cytotoxicity and in vitro cell cycle perturbations after exposure of human ovarian cancer cells to seven cytotoxic agents. RESULTS: Three principal patterns of cell cycle alterations were observed; a sequential S-G/M block after exposure to the non phase-specific agents cis-platinum, 4-hydroperoxy-eyclophosphamide, and mitomycin C (Group I); an isolated G2/M block after exposure to the G2/M phase-specific drugs etoposide and vincristine (Group II); and an isolated S block following exposure to the S phase-specific agents 5-fluorouracil and cytosine arabinoside (Group III). Overall, there was no direct correlation between the degree of cell cycle perturbations and cytotoxicity. However, when the three subgroups of phase non-specific agents, S phase-specific agents, and G2/M specific agents were analyzed separately, positive correlations between the magnitude of cell kinetic alterations and cytotoxicity were observed. CONCLUSIONS: Cell kinetic alterations appeared to precede cytotoxicity. The experimental model may be particularly useful to study cell kinetic effects after high-dose chemotherapy since, in contrast to conventional chemotherapy, the magnitude of cell kinetic perturbations after this kind of treatment is significantly increased.
- Find related publications in this database (using NLM MeSH Indexing)
- Antineoplastic Agents - pharmacology
- Cell Cycle - drug effects
- Cell Line - drug effects
- Cell Survival - drug effects
- Dose-Response Relationship, Drug - drug effects
- Female - drug effects
- Humans - drug effects
- Ovarian Neoplasms - pathology
- Tumor Cells, Cultured - drug effects
- Find related publications in this database (Keywords)
- cell cycle perturbations
- cytotoxic chemotherapy
- ovarian cancer
- cytotoxicity
- highdose chemotherapy