Medizinische Universität Graz - Research portal
Selected Publication:
Eherer, AJ; Hinterleitner, TA; Petritsch, W; Holzer-Petsche, U; Beubler, E; Krejs, GJ.
Effect of 5-hydroxytryptamine antagonists on cholera toxin-induced secretion in the human jejunum.
Eur J Clin Invest. 1994; 24(10):664-668
Doi: 10.1111/j.1365-2362.1994.tb01058.x
Web of Science
PubMed
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- Leading authors Med Uni Graz
- Eherer Andreas
- Co-authors Med Uni Graz
- Beubler Eckhard
- Hinterleitner Thomas
- Holzer Ulrike
- Krejs Günter Josef
- Petritsch Wolfgang
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- Abstract:
- In rats, the combined administration of the 5-HT2 antagonist ketanserin and the 5-HT3 antagonist tropisetron inhibits cholera toxin-induced intestinal secretion. We investigated whether these agents and the 5-HT3 antagonist ondansetron can inhibit cholera toxin-induced secretion in the human jejunum using a segmental perfusion technique. In a first control period the subjects' jejunums were perfused continuously with a plasma-like electrolyte solution. In a second control period they either received a combination of tropisetron plus ketanserin, or tropisetron or ondansetron alone. Cholera toxin 6.25 micrograms was then administered intrajejunally and the experiments were continued for 4 h. Net water movements during the 4th hour after CT administration minus net water movement during the first control period was used for further calculation and was referred to as net luminal gain. In perfusion studies with tropisetron plus ketanserin resp. ondansetron the net luminal gain of water (+ 161 +/- 26 resp. 189 +/- 28 ml 30 cm-1 h-1, mean +/- SEM) was significantly higher compared to perfusion studies with cholera toxin alone (+ 94 +/- 30). Treatment with tropisetron did not change the CT-induced net luminal gain of water (+ 108 +/- 41). Movements of sodium, chloride, bicarbonate and potassium paralleled the movement of water. In agreement with these observations we found a deterioration of clinical parameters after the end of the perfusion studies in four of five subjects treated with CT 25 micrograms plus ketanserin and tropisetron.(ABSTRACT TRUNCATED AT 250 WORDS)
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Biological Transport - drug effects
- Cholera Toxin - antagonists and inhibitors Cholera Toxin - pharmacology
- Electrolytes - metabolism
- Humans -
- Indoles - pharmacology
- Jejunum - drug effects Jejunum - secretion
- Ketanserin - pharmacology
- Serotonin Antagonists - pharmacology
- Water - metabolism
- Find related publications in this database (Keywords)
- Cholera Toxin
- Human
- Intestinal Secretion
- Ketanserin
- Ondansetron
- Tropisetron