Medizinische Universität Graz - Research portal

Go directly to the nagivation.
Go directly to the content.

Navigation/Search

Selected Publication:

DONNERER, J; YAN, Z; LEMBECK, F.
Effects of clonidine and yohimbine on a C-fibre-evoked blood pressure reflex in the rat.
BRIT J PHARMACOL. 1988; 94(3): 848-852. Doi: 10.1111/j.1476-5381.1988.tb11596.x [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG Google Scholar

Leading authors Med Uni Graz: Donnerer Josef
Altmetrics:
Dimensions Citations:
Plum Analytics:
Scite (citation analytics):
Abstract:: 1. The involvement of alpha 2-adrenoceptors in a capsaicin-induced depressor reflex in the rat has been investigated. 2. The reflex fall in blood pressure following an intra-arterial injection of capsaicin was partially blocked by an intrathecal infusion of clonidine (1 microgram) at the spinal cord level L4-L5, an effect which was abolished by the prior intrathecal infusion of yohimbine (5 micrograms). 3. Clonidine (1 microgram) given intracisternally blocked the depressor reflex almost completely; however, it also produced a gradual, prolonged fall in mean carotid pressure. 4. Yohimbine (20 micrograms) given intracisternally did not change mean blood pressure but had a dual effect on the depressor reflex in response to the capsaicin injection: a short period of enhanced reflex response was followed by a long lasting inhibition of the response. 5. It was concluded that alpha 2-adrenoceptors in the spinal cord inhibit the capsaicin-evoked depressor reflex and that pre- and postsynaptic alpha 2-adrenoceptors in the brain stem modulate this reflex.
Find related publications in this database (using NLM MeSH Indexing): Animals -; Blood Pressure - drug effects; Capsaicin - antagonists and inhibitors; Cisterna Magna - antagonists and inhibitors; Clonidine - administration and dosage; Female - administration and dosage; Injections - administration and dosage; Injections, Spinal - administration and dosage; Male - administration and dosage; Nerve Fibers - drug effects; Rats - drug effects; Rats, Inbred Strains - drug effects; Reflex - drug effects; Yohimbine - administration and dosage