Medizinische Universität Graz - Research portal
Selected Publication:
LEMBECK, F; DECRINIS, M; PERTL, C; AMANN, R; DONNERER, J.
Effects of endothelin on the cardiovascular system and on smooth muscle preparations in different species.
Naunyn Schmiedebergs Arch Pharmacol. 1989; 340(6 Pt 2):744-751
Doi: 10.1007/BF00169684
Web of Science
PubMed
FullText
FullText_MUG
Google Scholar
- Co-authors Med Uni Graz
- Donnerer Josef
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- (1) The actions of porcine endothelin (ET), an endothelium-derived vasoconstrictor peptide, have been investigated in several in vitro smooth and cardiac muscle preparation as well as on the blood pressure of anaesthetized rats and rabbits. (2) In isolated visceral smooth muscles (guinea pig ileum, rat colon and uterus, rabbit jejunum) ET caused a long-lasting contraction which persisted after repeated rinsing. ET did not interfere with the spontaneous phasic activity of the rabbit jejunum or with contractions evoked by histamine or carbachol. (3) ET contracted isolated blood vessels (portal vein of guinea-pig and rat). In isolated perfused organs (rabbit ear, guinea-pig lung, rat mesentery and hindpaw) ET led to a long-lasting vasoconstriction. In the isolated perfused guinea-pig lung ET caused vaso- and bronchoconstriction. (4) ET produced a long-lasting positive inotropic effect in spontaneously beating isolated guinea-pig atria. The positive inotropic action of strophanthin was augmented in the presence of ET. (5) In the isolated perfused guinea-pig and rat hearts the prominent effect of ET was a long-lasting coronary vasoconstriction. (6) Pithed rats responded to i.v. injection of ET with a long-lasting increase in blood pressure. In pentobarbitone anaesthetized rats pretreated either with atropine, with guanethidine plus atropine, or with guanethidine plus atropine plus indomethacin, the long-lasting increase in blood pressure was smaller than in pithed rats whereas the initial short-lasting decrease in blood pressure was more pronounced; in pentobarbitone anaesthetized rabbits endothelin caused bronchoconstriction, a decrease in blood pressure and a pronounced increase in central venous pressure possibly resulting from pulmonary or coronary artery constriction or a combination of both effects.(ABSTRACT TRUNCATED AT 250 WORDS)
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Bleeding Time -
- Cardiovascular System - drug effects
- Colon - drug effects
- Decerebrate State - drug effects
- Ear, External - blood supply
- Endothelins - blood supply
- Female - blood supply
- Guinea Pigs - blood supply
- Heart - drug effects
- Hindlimb - blood supply
- Ileum - drug effects
- Jejunum - drug effects
- Male - drug effects
- Mesenteric Arteries - drug effects
- Muscle, Smooth, Vascular - drug effects
- Peptides - pharmacology
- Portal Vein - drug effects
- Rabbits - drug effects
- Rats - drug effects
- Species Specificity - drug effects
- Uterus - drug effects