Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Cervar, M; Kainer, F; Jones, CJ; Desoye, G.
Altered release of endothelin-1,2 and thromboxane B2 from trophoblastic cells in pre-eclampsia.
Eur J Clin Invest. 1996; 26(1):30-37
Doi: 10.1046%2Fj.1365-2362.1996.87238.x
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- Führende Autor*innen der Med Uni Graz
- Cervar-Zivkovic Mila
- Desoye Gernot
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- Abstract:
- The aim of the study was to investigate whether pre-eclampsia is associated with an altered release of vasoactive substances from trophoblastic cells in vitro. Trophoblastic cells from 15 uncomplicated control pregnancies and 18 pre-eclamptic pregnancies at preterm (weeks 31-36; n = 12) and term (weeks 37-40; n = 21) were cultured for 5 days. The concentrations of angiotensin II (AII), endothelin-1,2 (ET-1,2), thromboxane B2 (TXB2), 6-keto-prostaglandin F1 alpha (6-keto-PGF1 alpha) and leukotriene B4 (LTB4) were measured daily in culture media for 5 days by radioimmunoassay. In pre-eclampsia, concentrations of ET-1,2 were decreased (P < 0.01) at both preterm and term, TXB2 concentrations were increased (P < 0.05) only at preterm and the TXB2-6-keto-PGF1 alpha ratio was increased at both preterm and term (P < 0.01) as compared with the controls. Concentrations of AII, 6-keto-PGF1 alpha and LTB4 were similar to the controls. The data suggest that pre-eclampsia is associated with a decreased release of ET-1 and an increased release of TXB2 from trophoblastic cells in vitro.
- Find related publications in this database (using NLM MeSH Indexing)
- 6-Ketoprostaglandin F1 alpha - metabolism
- Adult - metabolism
- Cell Survival - physiology
- Cells, Cultured - metabolism
- Endothelins - metabolism
- Epoprostenol - metabolism
- Female - metabolism
- Humans - metabolism
- Immunohistochemistry - metabolism
- Leukotriene B4 - metabolism
- Pre-Eclampsia - metabolism
- Pregnancy - metabolism
- Pregnancy Trimester, Third - metabolism
- Radioimmunoassay - metabolism
- Thromboxane A2 - metabolism
- Thromboxane B2 - metabolism
- Trophoblasts - cytology
- Vasodilator Agents - metabolism
- Find related publications in this database (Keywords)
- Endothelin
- Preeclampsia
- Thromboxane
- Trophoblast