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SHR Neuro Cancer Cardio Lipid Metab Microb

Coenen, M; Malinowski, K; Spitzer, W; Schuchert, A; Schmitz, D; Anelli-Monti, M; Maier, SKG; Estlinbaum, W; Bauer, A; Muehling, H; Kalscheur, F; Puerner, K; Boergel, J; Osswald, S.
Closed loop stimulation and accelerometer-based rate adaptation: results of the PROVIDE study.
Europace. 2008; 10(3):327-333 Doi: 10.1093/europace/eun024 [OPEN ACCESS]
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Co-authors Med Uni Graz: Anelli-Monti Michael
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Abstract:: AIMS: We compared pacing rate adaptation based on closed loop stimulation (CLS) or accelerometer sensor (AS) during acute mental and physical stress in the same patient. METHODS AND RESULTS: One month after Protos (Biotronik, Germany) pacemaker implantation, 131 chronotropically incompetent patients were randomized to AS or CLS for 3 months with crossover. Arithmetic and 6 min walk tests were performed in the non-rate-adaptive mode and AS and CLS rate-adaptive modes, respectively. At the end, patients had to select the individually preferred pacemaker sensor. Heart rate during mental stress was higher (3.0 +/- 9.2 bpm) in the CLS than in the AS mode (P = 0.004). Benefit in the walking distance compared with non-rate-adaptive pacing was similar for the two modes: added 27 +/- 96 m (AS, P = 0.013) and 30 +/- 116 m (CLS, P = 0.025). At the end of the walk, heart rate was higher by 4.8 +/- 21.4 bpm in AS than in CLS (P = 0.049). Twice as many patients preferred CLS over AS (P < 0.01). CONCLUSION: The arithmetic test was associated with a significantly higher heart rate for CLS than for AS, showing a greater sensitivity of CLS-based rate adaptation to mental stress. Performance during physical stress was comparable. Patients preferred CLS.
Find related publications in this database (using NLM MeSH Indexing): Adaptation, Physiological - physiology; Aged -; Aged, 80 and over -; Cardiac Pacing, Artificial - methods; Cross-Over Studies -; Exercise Test -; Female -; Follow-Up Studies -; Heart Rate - physiology; Humans -; Intelligence Tests -; Male -; Middle Aged -; Pacemaker, Artificial -; Patient Satisfaction -; Prospective Studies -
Find related publications in this database (Keywords): rate-adaptive pacing; chronotropic incompetence; closed loop stimulation; accelerometer sensor; mental stress; physical stress