Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Coenen, M; Malinowski, K; Spitzer, W; Schuchert, A; Schmitz, D; Anelli-Monti, M; Maier, SKG; Estlinbaum, W; Bauer, A; Muehling, H; Kalscheur, F; Puerner, K; Boergel, J; Osswald, S.
Closed loop stimulation and accelerometer-based rate adaptation: results of the PROVIDE study.
Europace. 2008; 10(3):327-333
Doi: 10.1093/europace/eun024
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- Co-Autor*innen der Med Uni Graz
- Anelli-Monti Michael
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- Abstract:
- AIMS: We compared pacing rate adaptation based on closed loop stimulation (CLS) or accelerometer sensor (AS) during acute mental and physical stress in the same patient. METHODS AND RESULTS: One month after Protos (Biotronik, Germany) pacemaker implantation, 131 chronotropically incompetent patients were randomized to AS or CLS for 3 months with crossover. Arithmetic and 6 min walk tests were performed in the non-rate-adaptive mode and AS and CLS rate-adaptive modes, respectively. At the end, patients had to select the individually preferred pacemaker sensor. Heart rate during mental stress was higher (3.0 +/- 9.2 bpm) in the CLS than in the AS mode (P = 0.004). Benefit in the walking distance compared with non-rate-adaptive pacing was similar for the two modes: added 27 +/- 96 m (AS, P = 0.013) and 30 +/- 116 m (CLS, P = 0.025). At the end of the walk, heart rate was higher by 4.8 +/- 21.4 bpm in AS than in CLS (P = 0.049). Twice as many patients preferred CLS over AS (P < 0.01). CONCLUSION: The arithmetic test was associated with a significantly higher heart rate for CLS than for AS, showing a greater sensitivity of CLS-based rate adaptation to mental stress. Performance during physical stress was comparable. Patients preferred CLS.
- Find related publications in this database (using NLM MeSH Indexing)
- Adaptation, Physiological - physiology
- Aged -
- Aged, 80 and over -
- Cardiac Pacing, Artificial - methods
- Cross-Over Studies -
- Exercise Test -
- Female -
- Follow-Up Studies -
- Heart Rate - physiology
- Humans -
- Intelligence Tests -
- Male -
- Middle Aged -
- Pacemaker, Artificial -
- Patient Satisfaction -
- Prospective Studies -
- Find related publications in this database (Keywords)
- rate-adaptive pacing
- chronotropic incompetence
- closed loop stimulation
- accelerometer sensor
- mental stress
- physical stress