Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Dyrby, TB; Rostrup, E; Baaré, WF; van Straaten, EC; Barkhof, F; Vrenken, H; Ropele, S; Schmidt, R; Erkinjuntti, T; Wahlund, LO; Pantoni, L; Inzitari, D; Paulson, OB; Hansen, LK; Waldemar, G; on behalf of the LADIS study group.
Segmentation of age-related white matter changes in a clinical multi-center study.
Neuroimage. 2008; 41(2): 335-345.
Doi: 10.1016/j.neuroimage.2008.02.024
Web of Science
PubMed
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FullText_MUG
- Co-authors Med Uni Graz
- Ropele Stefan
- Schmidt Reinhold
- Study Group Members Med Uni Graz:
- Fazekas Franz
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- Abstract:
- Age-related white matter changes (WMC) are thought to be a marker of vascular pathology, and have been associated with motor and cognitive deficits. In the present study, an optimized artificial neural network was used as an automatic segmentation method to produce probabilistic maps of WMC in a clinical multi-center study. The neural network uses information from T1- and T2-weighted and fluid attenuation inversion recovery (FLAIR) magnetic resonance (MR) scans, neighboring voxels and spatial location. Generalizability of the neural network was optimized by including the Optimal Brain Damage (OBD) pruning method in the training stage. Six optimized neural networks were produced to investigate the impact of different input information on WMC segmentation. The automatic segmentation method was applied to MR scans of 362 non-demented elderly subjects from 11 centers in the European multi-center study Leukoaraiosis And Disability (LADIS). Semi-manually delineated WMC were used for validating the segmentation produced by the neural networks. The neural network segmentation demonstrated high consistency between subjects and centers, making it a promising technique for large studies. For WMC volumes less than 10 ml, an increasing discrepancy between semi-manual and neural network segmentation was observed using the similarity index (SI) measure. The use of all three image modalities significantly improved cross-center generalizability compared to neural networks using the FLAIR image only. Expert knowledge not available to the neural networks was a minor source of discrepancy, while variation in MR scan quality constituted the largest source of error.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Aged, 80 and over -
- Aging - physiology
- Brain - pathology
- Humans -
- Image Interpretation, Computer-Assisted - methods
- Magnetic Resonance Imaging -
- Neural Networks (Computer) -
- Find related publications in this database (Keywords)
- artificial neural network
- automatic segmentation
- disability
- elderly
- LADIS study
- Leukoaraiosis
- MRI
- white matter lesions