Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Kolluru, GK; Tamilarasan, KP; Geetha Priya, S; Durgha, NP; Chatterjee, S.
Cadmium induced endothelial dysfunction: consequence of defective migratory pattern of endothelial cells in association with poor nitric oxide availability under cadmium challenge.
Cell Biol Int. 2006; 30(5):427-438
Doi: 10.1016/j.cellbi.2006.02.002
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- Kuppusamy Palaniappan Tamilarasan
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- Abstract:
- Recent advances in cadmium toxicity research suggest an association between cadmium and vascular diseases. However, the mechanisms of cadmium implications in vascular diseases are not yet explained. The objective of our present study is to explore the mechanism of cadmium induced endothelial dysfunction. Doses of 0, 1 and 5microM cadmium chloride were used to test the effects of cadmium on nitric oxide induced tube formation, cellular migration and subcellular actin polymerization in ECV-304 endothelial cells. An egg-yolk vascular bed model was used to study the effects of cadmium on angiogenesis. Results of the present study show that 5microM cadmium chloride effectively inhibited angiogenesis, cellular migration and tube formation. Phalloidin staining, which represents actin polymerization of endothelial cells, reveals that cadmium induces an altered F-actin pattern, which could be the prime cause for cadmium mediated inhibition of cellular migration and angiogenesis. Cadmium was also found to inhibit nitric oxide production in endothelial cells in a calcium free medium, which further hints that cadmium might impair endothelial functions by inhibiting endothelial nitric oxide synthase.
- Find related publications in this database (using NLM MeSH Indexing)
- Biological Availability -
- Cadmium - toxicity
- Cell Movement - drug effects
- Cells, Cultured - drug effects
- Cytoskeleton - drug effects
- Endothelial Cells - drug effects
- Humans - drug effects
- Neovascularization, Pathologic - chemically induced
- Nitric Oxide - metabolism
- Wound Healing - drug effects
- Find related publications in this database (Keywords)
- angiogenesis
- cadmium
- F-actin
- migration
- nitric oxide