Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Lenart, J; Dombrowski, F; Görlach, A; Kietzmann, T.
Deficiency of manganese superoxide dismutase in hepatocytes disrupts zonated gene expression in mouse liver.
Arch Biochem Biophys. 2007; 462(2):238-244
Doi: 10.1016/j.abb.2007.02.007
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Lenart Jacek
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- Abstract:
- The liver acinus displays a physiological periportal to perivenous oxygen gradient. This gradient was implicated to use reactive oxygen species (ROS) as mediators for the zonal gene expression. Mitochondria use oxygen and produce ROS, therefore they may contribute to the zonation of gene expression. To further elucidate this, we used the Cre-loxP system to generate a hepatocyte-specific null mutation of the mitochondrial antioxidant enzyme manganese superoxide dismutase (MnSOD) in mice. We found that ROS levels were enhanced in livers of MnSOD(-/-) mice which were reduced in size and displayed signs of liver failure such as intracellular protein droplets, increased apoptotic bodies and Bax levels as well as multinuclear hepatocytes. Further, the zonation of glutamine synthetase, glucokinase and phosphoenolpyruvate carboxykinase was no longer preserved. We conclude that deficiency of mitochondrial MnSOD initiates a dysregulation of zonated gene expression in liver.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Hepatocytes - metabolism
- Liver - metabolism
- Liver Diseases - metabolism
- Mice - metabolism
- Mice, Inbred C57BL - metabolism
- Mice, Knockout - metabolism
- Oxygen - metabolism
- Reactive Oxygen Species - metabolism
- Superoxide Dismutase - deficiency
- Tissue Distribution - deficiency
- Find related publications in this database (Keywords)
- manganese superoxide dismutase
- liver zonation
- glutamine synthetase
- mitochondria
- inflammation liver failure
- reactive oxygen species