Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Lenart, J; Pikula, S.
10-Undecynoic acid, an inhibitor of cytochrome P450 4A1, inhibits ethanolamine-specific phospholipid base exchange reaction in rat liver microsomes.
Acta Biochim Pol. 1999; 46(1): 203-210.
Doi: 10.18388/abp.1999_4198
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- Führende Autor*innen der Med Uni Graz
- Lenart Jacek
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- Abstract:
- 1,12-Dodecanedioic acid, the end-product of omega-hydroxylation of lauric acid, stimulates in a concentration dependent manner, phosphatidylethanolamine synthesis via ethanolamine-specific phospholipid base exchange reaction in rat liver endoplasmic reticulum. On the other hand, administration to rats of 10-undecynoic acid, a specific inhibitor of omega-hydroxylation reaction catalyzed by cytochrome P450 4A1, inhibits the ethanolamine-specific phospholipid base exchange activity by 30%. This is accompanied by a small but significant decrease in phosphatidylethanolamine content in the endoplasmic reticulum and inhibition of cytochrome P450 4A1. On the basis of these results it can be proposed that a functional relationship between cytochrome P450 4A1 and phosphatidylethanolamine synthesis exists in rat liver. Cytochrome P450 4A1 modulates the cellular level of lauric acid, an inhibitor of phospholipid synthesis. In turn, ethanolamine-specific phospholipid base exchange reaction provides molecular species of phospholipids, containing mainly long-chain polyunsaturated fatty acid moieties, required for the optimal activity of cytochrome P450 4A1.
- Find related publications in this database (using NLM MeSH Indexing)
- Alkane 1-Monooxygenase -
- Animals -
- Cytochrome P-450 Enzyme System - antagonists and inhibitors
- Enzyme Inhibitors - pharmacology
- Fatty Acids, Unsaturated - pharmacology
- Male - pharmacology
- Microsomes, Liver - drug effects
- Mixed Function Oxygenases - antagonists and inhibitors
- Phosphatidylethanolamines - metabolism
- Rats - metabolism
- Rats, Wistar - metabolism
- Find related publications in this database (Keywords)
- phospholipid synthesis
- base exchange reaction
- cytochrome P450 4A1
- clofibrate
- 10-undecynoic acid
- rat liver