Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Richter, B; Gwechenberger, M; Filzmoser, P; Marx, M; Lercher, P; Gössinger, HD.
Is inducibility of atrial fibrillation after radio frequency ablation really a relevant prognostic factor?
Eur Heart J. 2006; 27(21): 2553-2559.
Doi: 10.1093/eurheartj/ehl307
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- Co-authors Med Uni Graz
- Lercher Peter
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- Abstract:
- AIMS: The study was intended to assess the prognostic value of inducibility of atrial fibrillation (AF) after radio frequency ablation. METHODS AND RESULTS: Two hundred and thirty four patients with drug-resistant paroxysmal (n=165) or persistent AF (n=69) underwent either Lasso-guided segmental pulmonary vein isolation (n=83) or CARTO-guided left atrial circumferential ablation (n=151). After ablation, two attempts to induce AF (>1 min) by decremental coronary sinus stimulation were performed. Patients were followed for at least 6 months (median: 12.7 months). At 6 months of follow-up, 67% of patients with paroxysmal and 48% of patients with persistent AF were AF-free. Inducibility of AF was a significant predictor of AF recurrence in univariate [hazard ratio (HR)=2.32, P<0.001] and multivariable (HR=2.19, P<0.001) Cox regression analyses. The prognostic value of inducibility was present in both patients with paroxysmal (HR=2.38, P=0.001) and persistent AF (HR=1.91, P=0.034) and did not significantly differ between both ablation techniques. The sensitivity, specificity, positive, and negative predictive values of the AF induction test to predict the 6-month ablation outcome were 46.7, 75, 53.8, and 69.2%, respectively. CONCLUSION: Inducibility of AF after ablation is a significant predictor of recurrent AF. However, owing to the low diagnostic accuracy of the AF induction test, non-inducibility does not qualify as reliable procedural endpoint.
- Find related publications in this database (using NLM MeSH Indexing)
- Atrial Fibrillation - diagnosis
- Catheter Ablation - methods
- Disease-Free Survival - methods
- Female - methods
- Follow-Up Studies - methods
- Humans - methods
- Male - methods
- Middle Aged - methods
- Prospective Studies - methods
- Pulmonary Veins - surgery
- Recurrence - prevention and control
- Sensitivity and Specificity - prevention and control
- Treatment Outcome - prevention and control
- Find related publications in this database (Keywords)
- atrial fibrillation
- catheter ablation
- inducibility
- arrhythmia
- electrophysiology