Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Hermann, JA; Hall, MA; Maini, RN; Feldmann, M; Brennan, FM.
Important immunoregulatory role of interleukin-11 in the inflammatory process in rheumatoid arthritis.
Arthritis Rheum. 1998; 41(8):1388-1397
Doi: 10.1002/1529-0131(199808)41:8<1388::AID-ART7>3.0.CO;2-F
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Hermann Josef
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- Abstract:
- OBJECTIVE: To investigate the possible immunoregulatory role of interleukin-11 (IL-11) in rheumatoid arthritis (RA). METHODS: IL-11 protein was assayed in RA tissue, and the effect of exogenous IL-11 on neutralization of endogenous IL-11 was investigated with respect to tumor necrosis factor alpha (TNFalpha), matrix metalloproteinase (MMP), and tissue inhibitor of metalloproteinases (TIMP) production. RESULTS: IL-11 was found in RA synovial membranes, synovial fluids, and blood sera. Blockade of endogenous IL-11 resulted in a 2-fold increase in TNFalpha levels, which increased to 22-fold if endogenous IL-10 was also blocked. Addition of exogenous IL-11 inhibited spontaneous TNFalpha production in RA synovium only in the presence of soluble IL-11 receptor. However, exogenous IL-11 directly inhibited spontaneous MMP-1 and MMP-3 production, and up-regulated TIMP-1 in RA synovial tissue. CONCLUSION: IL-11 has important endogenous immunoregulatory effects in RA synovium, which suggests that exogenous IL-11 may have therapeutic activity in RA.
- Find related publications in this database (using NLM MeSH Indexing)
- Adjuvants, Immunologic - physiology
- Arthritis, Rheumatoid - pathology
- Cells, Cultured - pathology
- Cytokines - biosynthesis
- Drug Interactions - biosynthesis
- Enzyme Inhibitors - pharmacology
- Fibroblasts - metabolism
- Humans - metabolism
- Inflammation Mediators - physiology
- Interleukin-1 - pharmacology
- Interleukin-10 - physiology
- Interleukin-11 - blood
- Metalloendopeptidases - antagonists and inhibitors
- Monocytes - metabolism
- Receptors, Interleukin - physiology
- Recombinant Proteins - physiology
- Solubility - physiology
- Synovial Fluid - metabolism
- Synovial Membrane - pathology
- Tumor Necrosis Factor-alpha - pharmacology