Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Bonelli, RM; Cummings, JL.
Frontal-subcortical circuitry and behavior.
Dialogues Clin Neurosci. 2007; 9(2): 141-151.
Doi: 10.31887/DCNS.2007.9.2/rbonelli
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- Führende Autor*innen der Med Uni Graz
- Bonelli Raphael
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- Abstract:
- The neuropsychiatric manifestations of neurodegenerative diseases are closely linked to neurocircuitry defects. Frontal-subcortical circuits, in particular, are effector mechanisms that allow the organism to act on its environment. In this paper, we present the three main frontal-subcortical circuits: the dorsolateral prefrontal circuit allows the organization of information to facilitate a response; the anterior cingulate circuit is required for motivated behavior; and the orbitofrontal circuit allows the integration of limbic and emotional information into behavioral responses. Impaired executive functions, apathy, and impulsivity are hallmarks of frontal-subcortical circuit dysfunction. A variety of other neuropsychiatric disorders, such as Tourette's syndrome, Huntington's disease, obsessive-compulsive disorder, attention-deficit/hyperactivity disorder, schizophrenia, and mood disorders may result from disturbances that have a direct or indirect impact on the integrity or functioning of these loops.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Brain Diseases - complications
- Emotions - physiology
- Gyrus Cinguli - anatomy and histology
- Humans - anatomy and histology
- Limbic System - anatomy and histology
- Mental Disorders - etiology
- Mood Disorders - etiology
- Neural Pathways - anatomy and histology
- Prefrontal Cortex - anatomy and histology