Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Prager, E; Wehrschuetz, M; Bisail, B; Woltsche, M; Schwarz, T; Lanz, H; Sorantin, E; Aigner, RM.
Comparison of 18F-FDG and 67Ga-citrate in sarcoidosis imaging.
NUKLEARMED-NUCL MED. 2008; 47(1): 18-23.
Doi: 10.3413/nukmed-0085
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Wehrschütz Eva
- Co-Autor*innen der Med Uni Graz
- Aigner Reingard
- Bisail Borjana
- Lanz Hadmar
- Schwarz Thomas
- Sorantin Erich
- Wehrschütz Martin
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- Abstract:
- Aim: Ga-67 citrate has been used long and successfully to diagnose and stage sarcoidosis. F-18-fluorodeoxyglucose (F-18-FDG) has been suggested as a positron emission tomography (PET) tracer for sarcoidosis imaging. This study aimed to analyze possible advantages of F-18-FDG-PET over 67Ga citrate scintigraphy during the primary assessment of patients with sarcoidosis. Patients and methods: Twenty-four patients (11 men, 13 women, aged 52 years +/- 12.4) with histologically proven sarcoidosis were investigated with F-18-FDG and Ga-67 citrate. Equipment included a full-ring PET scanner (ECAT EXACT HR+, Siemens/CTI, Knoxville TN, USA) and a double-headed gamma camera ([CAM, Siemens, Illinois, USA) for scintigraphy. The mean time difference between the two studies was 6.5 days (range: 5-8 days). Results: There was a significant difference in the detection of pulmonary and nonpulmonary sarcoidosis lesions between planar 67Ga citrate scans and F-18-FDG-PET images (< 0.0021). A total of 64 lesions were detected with Ga-67 citrate scans in the thorax and elsewhere with a mean of 2.6 lesions (4%) per patient, while 85 lesions were found with F-18-FDG-PET, with a mean of 3.5 lesions (4.1%) per patient. There was complete agreement between F-18-FDG and Ga-67 citrate in thoracic manifestations in four (16.6%) patients, and in non-thoracic manifestations in five (20.8%) patients. The interobserver variability showed a kappa value of 0.79. Conclusion: Ga-67 citrate and F-18-FDG are useful tracers for diagnostic evaluation of thoracic sarcoidosis. 18F-FDG seems to be more suitable for imaging the mediastinum, the bi-hilar lymph nodes, the posterior regions of the lungs and non-thoracic lesions. Further prospective studies are needed to clarify the role of both tracers in early diagnosis and staging of sarcoidosis, and to resolve questions concerning medical treatment and follow-up.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Blood Glucose - metabolism
- Citrates - diagnostic use
- Female -
- Fluorodeoxyglucose F18 - diagnostic use
- Gallium - diagnostic use
- Gallium Radioisotopes - diagnostic use
- Humans -
- Lung - pathology Lung - radionuclide imaging
- Male -
- Middle Aged -
- Radiopharmaceuticals - diagnostic use
- Sarcoidosis - blood Sarcoidosis - radionuclide imaging
- Whole-Body Irradiation -
- Find related publications in this database (Keywords)
- sarcoidosis
- 67 gallium citrate
- F-18-FDG