Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Mangge, H; Felsner, P; Herrmann, J; el-Shabrawi, Y; Liebmann, P; Schauenstein, K.
Early rheumatoid arthritis is associated with diminished numbers of TH1 cells in stimulated peripheral blood.
Immunobiology. 1999; 200(2):290-294
Doi: 10.1016/S0171-2985(99)80077-1
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Mangge Harald
- Co-Autor*innen der Med Uni Graz
- El-Shabrawi Yosuf
- Liebmann-Holzmann Peter
- Schauenstein Konrad
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- Abstract:
- Rheumatoid arthritis (RA) has been associated with an altered TH1/TH2 balance. Here we present first results with a technique to quantitate stimulated TH1 and TH2 subsets in whole blood by means of cytofluorimetric detection of intracytoplasmic TH1 and TH2 cytokines. A group of 10 patients suffering from initial stages of RA exhibited a significantly reduced percentage of TH1 cells (11.0 +/- 2.0%) in the peripheral blood as compared to 13 healthy, age matched controls (28.8 +/- 2.0%). The TH2 response, as determined by intracellular expression of IL-4, remained unchanged. The data may indicate a defect in the TH0-TH1 differentiation or/and a selective trapping of TH1 cells into the affected joints.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Aged, 80 and over -
- Antigens, CD3 - immunology
- Arthritis, Rheumatoid - immunology
- Female -
- Humans -
- Leukocytes, Mononuclear - immunology
- Male -
- Middle Aged -
- Th1 Cells - immunology
- Th2 Cells - immunology
- Time Factors -